Autophagy

Autophagy is an intracellular catabolic mechanism. In certain stressful situations, lysosomes degrade degenerated, damaged, aged or non-functional cells, organelles and biomolecules such as proteins and nucleic acids to achieve cellular protection and organelles from cell damage. Autophagy is achieved by forming a bilayer membrane structure in the cytoplasm that wraps the material to be removed and transports it to the lysosome for degradation. In multicellular organisms, newly formed autophagic vesicles form autophagic endosomes by fusing with vesicles in different stages of the endocytic lysosomal pathway, such as early endosomes and late endosomes, before fusing with lysosomes, a process known as autophagic vesicle maturation. Abnormalities in autophagosome maturation, which is precisely regulated by cellular trophic state and stress signaling pathways, lead to the accumulation of large amounts of damaged organelles and toxic protein aggregates in cells.

Cat. No.	Product name
BP12378	PF-3845
BP12378	PF-3845 is a potent, selective and irreversible FAAH inhibitor with Ki of 230 nM, showing negligible activity against FAAH2.
BP12379	Sulfuretin
BP12379	Sulfuretin is a potent anti-oxidant, has protective effect against t-BHP-induced oxidative damage in human liver-derived HepG2 cells is attributable to its ability to scavenge ROS and up-regulate the activity of HO-1 through the Nrf2/ARE and JNK/ERK signaling pathways.
BP12380	Retro-2
BP12380	Retro 2 is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Golgi network) interface.
BP12381	GPP78
BP12381	GPP78 is a potent inhibitor of Nampt (IC50: 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion). GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells (IC50: 3.8 nM by inducing autophagy). GPP78 has anti-cancer and anti-inflammatory effects.
BP12382	SRT3109
BP12382	SRT3109 is a CXCR2 ligand used in the treatment of chemokine mediated diseases and conditions.
BP12383	SRT3190
BP12383	SRT3190 is an antagonist of CXCR2.
BP12384	GDC-0349
BP12384	GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases. Phase 1.
BP12385	Indophagolin
BP12385	Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.
BP12386	CaMKII-IN-1
BP12386	CaMKII-IN-1 is a potent and highly selective inhibitor of CaMKII (IC50 = 63 nM). CaMKII-IN-1 exhibited more than 100-fold higher selectivity for CaMKII over CaMKIV, MLCK, p38a, Akt1, and PKC.
BP12387	JZL195
BP12387	JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor.
BP12388	Salvianolic acid B
BP12388	lithospermic acid B is a water-soluble antioxidant from Salvia extract. It plays significant role of antioxidant effect; antiplatelet aggregation, anticoagulant, and antithrombotic effect
BP12389	PTC-209 hydrobromide
BP12389	PTC-209 HBr is the hydrobromide salt of PTC-209, which is a potent and selective BMI-1 inhibitor with IC50 of 0.5 μM, and results in irreversible reduction of cancer-initiating cells (CICs).
BP12390	Dorsomorphin dihydrochloride
BP12390	Dorsomorphin is a potent, selective and ATP-competitive AMPK inhibitor (Ki: 109 nM) and does not exhibit significant activity on structurally related kinases.
BP12391	Skepinone-L
BP12391	Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
BP12392	Sulfanitran
BP12392	Sulfanitran is a sulfonamide antibiotic used in the poultry industry.
BP12393	Torin 1
BP12393	Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.
BP12394	Sapanisertib
BP12394	INK 128 is an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
BP12395	MDK-6983
BP12395	MDK-6983 is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.
BP12396	BIA 10-2474
BP12396	BIA10-2474 is a long-acting reversible inhibitor of fatty acid amide hydrolase (FAAH) that increases levels of the neurotransmitter anandamide in the central nervous system and in peripheral tissues (that is, the rest of the body other than the brain and spinal cord). BIA 10-2474 interacts with the human endocannabinoid system. BIA 10-2474 was in development for the treatment of a range of different medical conditions from anxiety to Parkinson's disease, also for the treatment of chronic pain of multiple sclerosis, Y, hypertension or the treatment of obesity.
BP12397	Topotecan
BP12397	Topotecan is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.