Autophagy

Autophagy is an intracellular catabolic mechanism. In certain stressful situations, lysosomes degrade degenerated, damaged, aged or non-functional cells, organelles and biomolecules such as proteins and nucleic acids to achieve cellular protection and organelles from cell damage. Autophagy is achieved by forming a bilayer membrane structure in the cytoplasm that wraps the material to be removed and transports it to the lysosome for degradation. In multicellular organisms, newly formed autophagic vesicles form autophagic endosomes by fusing with vesicles in different stages of the endocytic lysosomal pathway, such as early endosomes and late endosomes, before fusing with lysosomes, a process known as autophagic vesicle maturation. Abnormalities in autophagosome maturation, which is precisely regulated by cellular trophic state and stress signaling pathways, lead to the accumulation of large amounts of damaged organelles and toxic protein aggregates in cells.

Cat. No.	Product name
BP12818	XCT790
BP12818	XCT790 is a potent, selective and inverse agonist of estrogen-related receptor alpha(ERRα).
BP12819	Omeprazole
BP12819	Omeprazole is a proton pump inhibitor (PPI), Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
BP12820	Cilostazol
BP12820	Cilostazol is a Phosphodiesterase 3 Inhibitor. The mechanism of action of cilostazol is as a Phosphodiesterase 3 Inhibitor.
BP12821	Ketanserin
BP12821	Ketanserin is a quinazoline derivative and serotonin (5-hydroxytryptamine, 5HT) receptor subtype 2 (5-HTR2) antagonist with potential antihypertensive and antiplatelet activities. Following administration, ketanserin binds to and inhibits the signaling mediated by 5-HTR2, which inhibits serotonin-dependent vasoconstriction and platelet activation.
BP12822	N-Benzylpalmitamide
BP12822	N-benzylpalmitamide inhibits fatty acid amide hydrolase (FAAH) in a time-dependent manner and could potentially offer a good alternative for the treatment of pain, inflammation and CNS degenerative disorders.
BP12823	Schisandrin
BP12823	Schisandrin is a compound with anti-asthmatic, anti-cancer, and anti-inflammatory effects.
BP12824	VX-702
BP12824	VX-702 is a highly specific p38α MAPK inhibitor, 14-fold higher selectivity for the p38α than p38β. VX-702 is a small molecule investigational oral anti-cytokine therapy for treatment of inflammatory diseases, specifically rheumatoid arthritis (RA).
BP12825	Hydroxychloroquine sulfate
BP12825	Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa.
BP12826	Isradipine
BP12826	Isradipine is a dihydropyridine calcium channel blockers with antihypertensive and vasodilator activities. Isradipine blocks the calcium entry through the calcium ion channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles. This increases oxygen delivery due to an increased blood flow and reduces oxygen requirements due to decreasing in total peripheral resistance.
BP12827	Tanespimycin
BP12827	Tanespimycin (17-AAG) is a potent HSP90 inhibitor with an IC50 of 5 nM, having a 100-fold higher binding affinity for tumour cell derived HSP90 than normal cell derived HSP90. Tanespimycin depletes cellular STK38/NDR1 and reduces STK38 kinase activity. Tanespimycin also downregulates the stk38 gene expression.
BP12828	Artemotil
BP12828	Arteether is a new, fast-acting antimalarial drug.
BP12829	Olaparib
BP12829	Olaparib is a small molecule inhibitor of PARP1/PARP2 (IC50: 5/1 nM) but is less effective against the PARP tankyrase-1 (IC50: 1.5 μM).
BP12830	Dehydropachymic acid
BP12830	Dehydropachymic acid shows antiinflammatory activity.
BP12831	N6-Isopentenyladenosine
BP12831	N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity. N6-Isopentenyladenosine, an RNA modification found in cytokinins, regulates plant growth/differentiation and improves the efficiency
BP12832	KM11060
BP12832	KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma membrane.
BP12833	Ursolic acid
BP12833	Ursolic acid(Bungeolic acid), a natural pentacyclic triterpenoid carboxylic acid, shows anti-tumor effects.
BP12834	LC3-mHTT-IN-AN2
BP12834	5,7-dihydroxy-4-phenyl coumarin is found in the plant Passiflora serratodigitata with the antibacterial activity.
BP12835	Tomatidine
BP12835	Tomatidine acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. It activates autophagy either in mammal cells or C elegans.
BP12836	Doxazosin mesylate
BP12836	Doxazosin mesylate(UK 33274) is a quinazoline-derivative. It is a selectively antagonizes postsynaptic α1-adrenergic receptors.
BP12837	Paroxetine hydrochloride
BP12837	Paroxetine hydrochloride is a serotonin uptake inhibitor that is effective in the treatment of depression.