Autophagy

Autophagy is an intracellular catabolic mechanism. In certain stressful situations, lysosomes degrade degenerated, damaged, aged or non-functional cells, organelles and biomolecules such as proteins and nucleic acids to achieve cellular protection and organelles from cell damage. Autophagy is achieved by forming a bilayer membrane structure in the cytoplasm that wraps the material to be removed and transports it to the lysosome for degradation. In multicellular organisms, newly formed autophagic vesicles form autophagic endosomes by fusing with vesicles in different stages of the endocytic lysosomal pathway, such as early endosomes and late endosomes, before fusing with lysosomes, a process known as autophagic vesicle maturation. Abnormalities in autophagosome maturation, which is precisely regulated by cellular trophic state and stress signaling pathways, lead to the accumulation of large amounts of damaged organelles and toxic protein aggregates in cells.

Cat. No.	Product name
BP12798	Danshensu sodium salt
BP12798	Danshensu (sodium salt) is sodium salt of danshensu from the widely used Chinese herb Danshen. It can inhibited phenylephrine- and CaCl2-induced vasoconstriction in Ca2+-free medium.
BP12799	AICAR phosphate
BP12799	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. AICAR phosphate regulates the glucose and lipid metabolism. It inhibits proinflammatory cytokines and iNOS production.
BP12800	Sulfadiazine
BP12800	Sulfadiazine is a synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para-aminobenzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
BP12801	Adenosine 5′-diphosphoribose sodium
BP12801	Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) is a NAD+ metabolite. It is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. It also can enhance autophagy.
BP12802	Corynoxine
BP12802	Corynoxine is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells.
BP12803	Elubrixin
BP12803	Elubrixin inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM). Elubrixin can be used for inflammatory diseases such as inflammatory bowel disease and airway inflammation. Elubrixin is a potent, selective, competitive, reversible and orally active CXCR2 antagonist and an IL-8 receptor antagonist.
BP12804	Genipin
BP12804	Genipin, an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.
BP12805	Chlorpromazine hydrochloride
BP12805	Chlorpromazine hydrochloride is the prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
BP12806	LY2109761
BP12806	LY2109761 is a novel selective TGF-β receptor type I/II (TβRI/II) dual inhibitor with Ki of 38 nM and 300 nM, respectively; shown to negatively affect the phosphorylation of Smad2.
BP12807	Physalin H
BP12807	Physalin H is an Hh signaling inhibitor blocks GLI1-DNA-complex formation, it also strong quinone reductase induction activity with IR (Induction ratio, QR induction activity) value of 3.74±0.02. Physalin H shows immunosuppressive effects on T cells both in vitro and in vivo, and the immunosuppressive activity might be attributed to the suppression of T cell activation and proliferation, the modulation of Th1/Th2 cytokine balance and the induction of HO-1 in T cells. Physalin H shows significant in vitro leishmanicidal activities (0.92-19.4 microg/ml) against promastigotes of Leishmania major.Physalin H shows cytotoxic activity against a panel of human and murine cancer cell lines.
BP12808	BX795
BP12808	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than GSK3β.
BP12809	Ivermectin
BP12809	Ivermectin is a glutamate-gated chloride channel (GluCls) activator, with antiparasitic activity.
BP12810	Daurisoline
BP12810	Daurisoline is a hERG inhibitor and also an autophagy blocker.
BP12811	Meloxicam
BP12811	Meloxicam is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of meloxicam is as a Cyclooxygenase Inhibitor. The chemical classification of meloxicam is Nonsteroidal Anti-inflammatory Compounds.
BP12812	Avermectin B1
BP12812	Avermectin B1 (Abamectin) is served as anthelmintic and insecticide.
BP12813	Sulfathiazole
BP12813	Sulfathiazole, an organosulfur compound, has been served as a short-acting sulfa medicine.
BP12814	Sulfamethoxazole
BP12814	Sulfamethoxazole is a Sulfonamide Antimicrobial. The mechanism of action of sulfamethoxazole is as a Cytochrome P450 2C9 Inhibitor. The chemical classification of sulfamethoxazole is Sulfonamides.
BP12815	STF-31
BP12815	STF-31 is an inhibitor of glucose transporter 1 (GLUT1) with IC50 of 1 μM.
BP12816	Pirarubicin
BP12816	Pirarubicin is an anthracycline antibiotic. It is also a DNA/RNA synthesis inhibitor that intercalates into DNA and interacts with topoisomerase II, utilized as an antineoplastic agent.
BP12817	Felodipine
BP12817	Felodipine is a longlasting 1, 4-dihydropyridine calcium channel repressor.