Autophagy

Autophagy is an intracellular catabolic mechanism. In certain stressful situations, lysosomes degrade degenerated, damaged, aged or non-functional cells, organelles and biomolecules such as proteins and nucleic acids to achieve cellular protection and organelles from cell damage. Autophagy is achieved by forming a bilayer membrane structure in the cytoplasm that wraps the material to be removed and transports it to the lysosome for degradation. In multicellular organisms, newly formed autophagic vesicles form autophagic endosomes by fusing with vesicles in different stages of the endocytic lysosomal pathway, such as early endosomes and late endosomes, before fusing with lysosomes, a process known as autophagic vesicle maturation. Abnormalities in autophagosome maturation, which is precisely regulated by cellular trophic state and stress signaling pathways, lead to the accumulation of large amounts of damaged organelles and toxic protein aggregates in cells.

Cat. No.	Product name
BP12758	KU-55933
BP12758	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.
BP12759	Atropine sulfate monohydrate
BP12759	Atropine sulfate monohydrate, the sulfate salt of atropine, is a competitive muscarinic acetylcholine receptor antagonist.
BP12760	Megestrol acetate
BP12760	Megestrol acetate is a progestogen with actions and uses similar to those of the progestogens in general. Megestrol acetate also has anti-androgenic properties. It is given by mouth in the palliative treatment or as an adjunct to other therapy in endometrial carcinoma and in breast cancer. Megestrol acetate has been approved to treat anorexia and cachexia.
BP12761	Niacin
BP12761	Niacin is a water-soluble vitamin belonging to the vitamin B family, which occurs in many animal and plant tissues, with antihyperlipidemic activity. Niacin is converted to its active form niacinamide, which is a component of the coenzymes nicotinamide adenine dinucleotide (NAD) and its phosphate form, NADP.
BP12762	TWS119
BP12762	TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation
BP12763	Binimetinib
BP12763	Binimetinib (MEK162, ARRY-162, ARRY-438162) is an orally available inhibitor of MEK1/2 (IC50: 12 nM) in a cell-free assay.
BP12764	Sinomenine hydrochloride
BP12764	Sinomenine hydrochloride is extracted from Sinomenium Acutum Rehderett Wilson.
BP12765	Bromhexine hydrochloride
BP12765	Bromhexine hydrochloride is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus.
BP12766	Schisandrin B
BP12766	Schisandrin B has an antioxidant effect on rodent liver and heart.
BP12767	Schizandrin A
BP12767
BP12768	Procainamide hydrochloride
BP12768	Procainamide Hydrochloride is the hydrochloride salt form of procainamide, an amide derivative exhibiting class 1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks the influx of sodium ions into the cell, which leads to an increase in threshold for excitation and inhibit depolarization during phase 0 of the action potential.
BP12769	Oxaliplatin
BP12769	Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
BP12770	TOMATIDINE HYDROCHLORIDE
BP12770	A steriodal alkaloid structurally similar to Cyclopamine but does not inhibit hedgehog pathway. May be used as a negative control for Cyclopamine and KAAD-Cyclopamine. Tomatidine protects against muscle atrophy and boosting muscle growth.
BP12771	Sulfacetamide sodium monohydrate
BP12771	Sulfacetamide sodium monohydrate is a sulfonamide antibiotic. It has been investigated for the treatment of rosacea and pityriasis versicolor.
BP12772	Dimethyl fumarate
BP12772	Dimethyl fumarate, a fumarate derivative, is used as antiinflammatory and immunomodulatory agent.
BP12773	Turofexorate Isopropyl
BP12773	Turofexorate Isopropyl (XL335) is a potent, selective, and orally bioavailable FXR agonist with EC50 of 4 nM
BP12774	Berberine chloride
BP12774	Berberine hydrochloride is an alkaloid from Hydrastis canadensis L., Berberidaceae and also found in many other plants. It is relatively toxic to parenterally but has been used orally for various fungal and parasitic infections and an anti-diarrheal.
BP12775	Oxidopamine hydrobromide
BP12775	Oxidopamine hydrobromide is a neurotransmitter dopamine antagonist.
BP12776	Sulfanilamide
BP12776	Sulfanilamide can competitively inhibit bacterial enzyme dihydropteroate synthetase with IC50 of 320 μM.
BP12777	Tozasertib
BP12777	MK-0457 is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C). It shows selectivity against more than 190 different kinases.