Immunology & Inflammation

Carpinontriol B has antimicrobial activity, it at 40 ug/disk caused the formation of zones of inhibition. It also has anti-inflammatory activity, it shows considerable inhibition on the production of nitric oxide and reduces the production of interleukin-6 in dose-dependent manner in RAW 264.7 cells.

CAY 10465 is a selective and high-affinity AhR agonist, with a Ki of 0.2 nM, and shows no effect on estrogen receptor (Ki >100000 nM).

CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay).

CCR2 antagonist 4 is a potent and specific antagonist of CCR2(IC50s of 180 nM), and potently inhibits MCP-1-induced chemotaxis(IC50 of 24 nM).

CCR2-RA-[R] is a C-C chemokine receptor type 2 (CCR2) allosteric antagonist (IC50: 103 nM).

CCR8 antagonist 1 is an antagonist of C-C Motif Chemokine Receptor 8 (CCR8) with a Ki value of 1.6 nM.

CCX140 (CCX140-B) is an antagonist of CCR2.

CCX354 is a CCR1antagonist. It has anti-inflammatory activity.

CDDO-EA is an activator of the Nrf2/antioxidant response element.

Cenicriviroc Mesylate is a dual CCR2/CCR5 antagonist, also inhibits both HIV-1 and HIV-2 with anti-inflammatory and antiinfective activity.

Cephalotaxine is an antiviral and an antitumor agent.

CH-223191 is a potent and specific antagonist for aryl hydrocarbon receptor (AhR).

Chlorhexidine hydrochloride is a disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.

Cistanoside F shows vasorelaxant, and antioxidative effects, it shows a strong free radical scavenging activity on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.

Cnidicin has anti-allergic and anti-inflammatory activity, it inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells(IC50 value, 7.5 microM). Cnidicin exhibits a significant inhibition on the proliferation of cultured human tumor cells such as A549 (non small cell lung), SK-OV-3 (ovary), SK-MEL-2 (melanoma), XF498 (central nervous system) and HCT-15 (colon) in vitro.

Colistin is a cyclic polypeptide antibiotic from Bacillus colistinus, composed of Polymyxins E1 and E2.

Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B hepatoma cells.Corilagin has antiviral activity, reduces the cytotoxicity induced by EV71 or CA16 on Vero cells with and IC50 value of 5.6 and 32.33 μg/mL, respectively. Corilagin shows the potential to protect against HSV-1-induced encephalitis, and the beneficial effects may be mediated by inhibiting TLR2 signaling pathways.Corilagin has antifibrotics property and is potentiated in treating idiopathic pulmonary fibrosis(IPF), attenuates bleomycin-induced epithelial injury and fibrosis via inactivation of oxidative stress, proinflammatory cytokine release and NF-κB and TGF-β1 signaling. Solvent:Pyridine, Methanol, Ethanol, etc.

CORM-3 is a carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity.

COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.