Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15002	BAY 2416964
BP15002	BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the potential for cancer treatment.
BP15003	BBIQ
BP15003	BBIQ is a powerful vaccine adjuvant that enhances innate immune responses and it is a imidazoquinoline compound and a potent and selectively toll-like receptor 7 (TLR7) agonist with an EC50 of 59.1 nM for human TLR7.
BP15004	Benralizumab
BP15004	Benralizumab (MEDI-563) is an IL-5Rα-directed cytolytic monoclonal antibody that induces rapid, direct and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. It can be used for severe eosinophilic asthma.
BP15005	3-Oxobetulin
BP15005	Betulone is a triterpenoid. It has a role as a metabolite. It derives from a hydride of a lupane.
BP15006	BF738735
BP15006	BF738735 is a selective inhibitor of phosphatidylinositol 4-kinase III beta (PI4KIIIβ, IC50 = 5.7 nM) showing higher activity over α(IC50 = 1.7 μM). BF738735 exhibits a broad spectrum of antiviral activity.
BP15007	Bindarit
BP15007	Bindarit displays specific inhibition against monocyte chemotactic proteins MCP-1/CCL2, MCP-3/CCL7 and MCP-2/CCL8.
BP15008	BMS CCR2 22
BP15008	BMS CCR2 22 is a potent, specific and high affinity CC-type chemokine receptor 2 (CCR2) antagonist. It has excellent binding affinity (binding IC50 of 5.1 nM) and potent functional antagonism (calcium flux IC50 of 18 nM and chemotaxis IC50 of 1 nM).
BP15009	BMS-813160
BP15009	BMS-813160 is the first dual CCR2/CCR5 antagonist to enter Clinical development for cardiovascular.
BP15010	BMS-905
BP15010	BMS-905 is a potent dual inhibitors of TLR7 and TLR8 with good selectivity against TLR9 and other family members. BMS-905 can be used in studies about the treatment of diseases such as psoriasis, arthritis, and lupus.
BP15011	Bonafton
BP15011	Bonafton is an antiviral agent.
BP15012	Brevifolincarboxylic acid
BP15012	Brevifolincarboxylic acid is a natural product isolated from Polygonum capitatum, it has inhibitory effect on the aryl hydrocarbon receptor (AhR). Brevifolincarboxylic acid is an α-glucosidase inhibitor with an IC50 of 323.46 μM.
BP15013	Bropirimine
BP15013	Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
BP15014	Bunaprolast
BP15014	Bunaprolast shows significant inhibition of lipoxygenase and TXB2 release. Bunaprolast is a potent inhibitor of LTB4 production in human whole blood.
BP15015	IRAK4-IN-7
BP15015	CA-4948 (previously AU-4948) is a selective and potent IRAK4 kinase inhibitor with in vivo activity in a TLR4-induced cytokine release model.
BP15016	CAFESTOL
BP15016	CAFESTOL is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway.
BP15017	Camalexin
BP15017	Camalexin is a phytoalexin isolated from Camelina sativa. It has antifungal, antibacterial, antiproliferative, and anticancer activities. Camalexin can induce ROS production.
BP15018	Camstatin acetate
BP15018	Camstatin acetate binds calmodulin and inhibits neuronal nitric oxide synthase. Camstatin acetate is a functionally active 25-residue fragment of the single calmodulin-binding IQ motif of PEP-19.
BP15019	Carbenicillin disodium
BP15019	Carbenicillin Disodium is a broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity.
BP15020	Carbidopa monohydrate
BP15020	Carbidopa Hydrate is an inhibitor of DOPA decarboxylase, preventing the conversion of levodopa to dopamine.
BP15021	Carbidopa
BP15021	Carbidopa is an aromatic-L-amino-acid decarboxylase inhibitor (IC50: 29±2 μM). It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA.