Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15042	CP-105696
BP15042	CP-105696 is a selective antagonist of Leukotriene B4 Receptor (IC50: 8.42 nM).
BP15043	TLR3-IN-1
BP15043	CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
BP15044	CU-115
BP15044	CU-115 is a selective antagonist of TLR8 with IC50s of 1.04 µM and >50 µM for TLR8 and TLR7, respectively.
BP15045	CU-CPT22
BP15045	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It competes with the synthetic triacylated lipoprotein (Pam3CSK4) binding to TLR1/2 (Ki: 0.41 μM).
BP15046	Curvularin
BP15046	Curvulin, naturally isolated from Campylobacter curvulans, is a fungal metabolite and a potent mycotoxin that inhibits cytokine-induced nitric oxide synthase (iNOS) with IC50 of 9.5 μM.
BP15047	Cyclomorusin
BP15047	Cyclomorusin exhibits competitive inhibition toward monophenolase activity of mushroom tyrosinase, the IC50 value of 0.092 microM. It evokes the stimulation of superoxide anion generation in fMLP-stimulated rat neutrophils. Cyclomorusin, neocyclomorusin and kuwanon C inhibited cholinesterase enzyme in a dose-dependent manner with K(i) values ranging between 3.1 and 37.5 uM and between 1.7 and 19.1 uM against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes, respectively.
BP15048	Dactylorhin A
BP15048	Dactylorhin A, a succinate derivative ester, is isolated from rhizomes of Gymnadenia conopsea. Dactylorhin A exhibits moderate inhibitory effect on NO production effects in RAW 264.7 macrophage cells.
BP15049	Dapansutrile
BP15049	Dapansutrile is a potent, selective and orally active NLRP3 inflammasome inhibitor, with Anti-inflammatory and analgesic activity.
BP15050	Deacetylasperulosidic Acid
BP15050	Deacetylasperulosidic acid is a natural compound of Morinda citrifolia fruit. It has antioxidant activity by increasing superoxide dismutase activity. It also prevents 4-nitroquinoline 1-oxide (4NQO) induced DNA damage in vitro, suppresses IL-2 production along with the activation of natural killer cells.
BP15051	Dehydroandrographolide
BP15051	Dehydroandrographolide is a natural compound extracted from herbal medicine Andrographis paniculata (Burm f) Nees.
BP15052	Dehydrogeijerin
BP15052	Dehydrogeijerin significantly inhibits the inflammatory activity of activated macrophages, suggesting that it could be a potential candidate for the treatment of inflammatory disease.
BP15053	Delphinidin-3-sambubioside chloride
BP15053	Delphinidin-3-sambubioside chloride has antioxidant activity.
BP15054	Desmethyl Celecoxib
BP15054	Demethyl celecoxib is a selective inhibitor of COX-2 with anti-inflammatory activity (IC50 of 32 nM). with anti-inflammatory activities. Desmethyl Celecoxib is an analog of Celecoxib and with the optimal yield of 75%.
BP15055	Dihydrotanshinone I
BP15055	Dihydrotanshinone I is a natural compound extracted from Salvia miltiorrhiza Bunge used for treating of cardiovascular diseases.
BP15056	Di-O-methyldemethoxycurcumin
BP15056	Di-O-methyldemethoxycurcumin is a Curcumin analog isolated from medicinal plant turmeric di-orthomethyldemethoxycurcumin, anti-inflammatory and antioxidant properties Inhibition of IL-6 production, EC50 is 16.20μg/mL.
BP15057	Diosmin
BP15057	Diosmin is a bioflavonoid that strengthens vascular walls.
BP15058	DMNQ
BP15058	DMNQ is a 1,4-naphthoquinone that acts as a redox-cycling agent, typically increasing intracellular superoxide and hydrogen peroxide formation.DMNQ increases ROS generation
BP15059	DW-1350
BP15059	DW-1350 is an antagonist of LTB4 receptor.
BP15060	Ecabet Sodium
BP15060	Ecabet sodium: a potential new agent in the management of distal colitis.
BP15061	Efaproxiral Sodium
BP15061	Efaproxiral Sodium, a synthetic allosteric modifier of hemoglobin, is utilized for brain metastases originating from breast cancer.