Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15222	Tormentic acid
BP15222	Tormentic acid is a natural product. It has anticancer, anti-inflammatory, anti-atherogenic, anti-allodynic, and hepatoprotective properties,
BP15223	Totaradiol
BP15223	Totaradiol shows antioxidant activity, it can inhibit linoleic acid autoxidation but not generation of superoxide anion. Totaradiol exhibits cytotoxic activity against the A2780 ovarian cancer cell line.
BP15224	Triptoquinone A
BP15224	Triptoquinone A may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. Triptoquinone A has anti-inflammatory activity, it prevents ndotoxin-or interleukin-1 beta-promoted induction of nitric oxide synthase in vascular smooth muscle, thus inhibiting development of L-arginine-induced vasorelaxation.
BP15225	Triptoquinone B
BP15225	Triptoquinone B is a novel interleukin-1 inhibitor, shows extremely potent inhibitory activities against interleukin-lα and β releases for human peripheral mononticlear cells, it shows the significant immunosuppressive activity.
BP15226	Tsugaric acid A
BP15226	Tsugaric acid A can significantly inhibit superoxide anion formation in fMLP/CB-stimulated rat neutrophils, it is also able to protect human keratinocytes against damage induced by ultraviolet B (UV B) light, indicates that tsugaric acid A can protect keratinocytes from photodamage.
BP15227	Tuberosin
BP15227	Tuberosin shows anti-inflammatory and antioxidant activities.It demonstrated a significantly potent inhibition on yeast α-glucosidase in a dose dependent manner.
BP15228	Tubuloside A
BP15228	Tubuloside A ( 8.6 microM) can inhibit D-galactosamine-induced death of hepatocytes. Tubuloside A has NO radical-scavenging activity, which possibly contributes to its anti-inflammatory effects.Tubuloside A shows stronger free radical scavenging activities than alpha-tocopherol on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and xanthine/xanthine oxidase (XOD) generated superoxide anion radical (O2-.).
BP15229	Umbelliprenin
BP15229	Umbelliprenin alleviated neuropathic pain, and decreased serum IL-6 levels and oxidative stress.
BP15230	VAF347
BP15230	VAF347 is a cell-permeable and highly affinity agonist of the aryl hydrocarbon receptor (AhR) with anti-inflammatory effects.
BP15231	Valdecoxib
BP15231	Valdecoxib is a prescription drug used in the treatment of osteoarthritis, rheumatoid arthritis, and painful menstruation and menstrual symptoms. It is classified as a nonsteroidal anti-inflammatory drug, or NSAID, and should not be taken by anyone allergic to these types of medications.
BP15232	Veliflapon
BP15232	Veliflapon is an orally active and selective inhibitor of 5-lipoxygenase activating protein (FLAP). Veliflapon inhibits the synthesis of the leukotrienes B4 and C4.
BP15233	Visomitin
BP15233	Visomitin is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS).
BP15234	Vitexilactone
BP15234	Vitexilactone is a HIV-1 reverse transcriptase inhibitor in virtual screening against Indonesian Herbal Database using AutoDock4 performed on HIV-1 reverse transcriptase. It has trypanocidal activity, the minimum lethal concentration against epimastigotes of Trypanosoma cruzi is 66 microM.Vitexilactone is one anticancer component of Vitex trifolia L., which exerts its anti-proliferative effect on cancer cells through inducing apoptosis and inhibiting the cell cycle.
BP15235	WY-135
BP15235	WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).
BP15236	Yadanziolide A
BP15236	Yadanziolide A is a natural product isolated from the cultivated dry seeds of Brucea javanica, has strong antiviral activities with IC50 of 5.5 μM against tobacco mosaic virus. Yadanziolide A shows significant antitumor effects.
BP15237	YL-109
BP15237	YL-109, a novel anticancer agent, can inhibit breast Y cell growth and invasiveness in vitro and in vivo.
BP15238	YM022
BP15238	YM022 is a highly effective and selective gastrin/cholecystokinin (CCK)-B receptor antagonist. YM022 can inhibit gastrin-induced gastric acid secretion and histidine decarboxylase activation in vivo. YM022 shows the Ki values of 68 pM and 63 nM for CCK-B and CCK-A receptor, respectively.
BP15239	ZK 756326
BP15239	ZK 756326 is a selective, non-peptide CCR8 chemokine receptor agonist (IC50: 1.8 μM, in human; 2.6 μM, in mouse). Displays no activity at CCR4/5 and CXCR3/4 and shows higher 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
BP15240	γ-Linolenic Acid methyl ester
BP15240	γ-Linolenic Acid methyl ester is a weak leukotriene B4 (LTB4) receptor antagonist.
BP15241	CU-CPD107
BP15241