Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15182	Quercimeritrin
BP15182	Quercimeritrin has antibacterial activity, it shows promising activity against Staphylococcus aureus.
BP15183	Riamilovir
BP15183	Riamilovir is a broad-spectrum antiviral drug candidate.
BP15184	Riboflavin Tetrabutyrate
BP15184	Riboflavin Tetrabutyrate is a lipophilic flavin derivative. Riboflavin Tetrabutyrate has antioxidative and lipid peroxide-removing activity.
BP15185	RO2959 Hydrochloride
BP15185	RO2959 hydrochloride is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2.
BP15186	Rofecoxib
BP15186	Rofecoxib binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in an inhibition of the conversion of arachidonic acid to prostaglandins. Rofecoxib is a synthetic, nonsteroidal derivative of phenyl-furanone with anti-inflammatory, antipyretic and analgesic properties and potential antineoplastic properties. COX-related metabolic pathways may represent key regulators of cell proliferation and neo-angiogenesis. Some epithelial tumor cell types overexpress pro-angiogenic COX-2.
BP15187	RS 504393
BP15187	RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1).
BP15188	Rutaevin
BP15188	Rutaevin shows the inhibitory activity on nitric oxide (NO) production in lipopolysaccharide-activated RAW264.7 macrophages, it may be as a valuable anti-inflammatory agent.
BP15189	RWJ 63556
BP15189	RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.
BP15190	Salicylamide
BP15190	Salicylamide is an over-the-counter drug with analgesic and antipyretic properties, which has similar medicinal properties to aspirin. In the over-the-counter pain remedies, Salicylamide is used in combination with both aspirin and caffeine.
BP15191	Sanggenon D
BP15191	Sanggenone D represents a new scaffold of positive GABAA receptor modulators, it also inhibits COX-2 activity (IC 50 = 73-100 μM). Sanggenone D has anti-inflammatory activity, it can inhibit NO production from lipopolysaccharide (LPS)-induced RAW 264.7 cells at > 10 uM; inhibition of nitric oxide production was mediated by suppression of iNOS enzyme induction but not by direct inhibition of iNOS enzyme activity.
BP15192	SB297006
BP15192	SB 297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg).
BP15193	SC57666
BP15193	SC57666 is a selective inhibitor of COX2(IC50 of 26 nM).
BP15194	SC58451
BP15194	SC58451 is a potent and selective inhibitor of Cox-2.
BP15195	Secologanic acid
BP15195	Secologanic acid is a plant growth inhibitor, it shows inhibition of nitric oxide production in lipopolysaccharide-activated macrophages.
BP15196	Sikokianin C
BP15196	Sikokianin C shows antimalarial activity against the chloroquine-resistant strain of Plasmodium falciparum, with the IC (50) value of 0.56 microg/mL.
BP15197	S-Methylisothiourea sulfate
BP15197	S-Methylisothiourea sulfate is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock.
BP15198	S-MTC
BP15198	S-MTC is a selective inhibitor of type I nitric oxide synthase.
BP15199	S-Nitroso-N-acetyl-DL-penicillamine
BP15199	S-Nitroso-N-acetyl-DL-penicillamine acts as a stable inhibitor of platelet aggregation, is a nitric oxide donor and.
BP15200	StemRegenin 1
BP15200	StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor.
BP15201	Stylopine hydrochloride
BP15201	Stylopine is a protoberberine-type alkaloid that has potential biological activities, including anti-inflammatory activity.