Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15162	NoxA1ds acetate(1435893-78-9 free base)
BP15162	NoxA1ds acetate is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC50 : 20 nM). Exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. Inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. Attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.
BP15163	NSC23925
BP15163	NSC23925 is a selective and effective inhibitor of P-glycoprotein (Pgp).
BP15164	Obtucarbamate A
BP15164	Obtucarbamate A isolated from Disporum cantoniense has antitussive activity.It has antitussive activity, it exhibits significant inhibitory effect against neuroinflammation with the IC50 value of 10.57 μM.
BP15165	Octahydrocurcumin
BP15165	Octahydrocurcumin has antioxidant and and anti-inflammatory activities, it can inhibit the lipopolysaccharide (LPS)-induced inflammatory response via the mechanism of inhibiting NF-kB translocation to the nucleus. Octahydrocurcumin exhibits potent cytotoxic effect (IC50 =19.46 ug/mL) and shows high antimicrobial activity.
BP15166	Okanin
BP15166	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
BP15167	Olsalazine disodium
BP15167	Olsalazine sodium is bioconverted to 5-aminosalicylic acid (5-ASA) in the colon and has anti-inflammatory activity in ulcerative colitis.
BP15168	Oxaprozin
BP15168	Oxaprozin is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compounds.
BP15169	Oxyphenbutazone
BP15169	Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
BP15170	Paeonilactone B
BP15170	Paeonilactone B is a natural product from Paeonia albiflora.
BP15171	PDM2
BP15171	PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
BP15172	Pelargonidin chloride
BP15172	Pelargonidin chloride shows protective effect against CTN-induced oxidative stress in HepG2 cells and up-regulated the activity of detoxification enzyme levels through Keap1/Nrf2 signaling pathway.
BP15173	PF-04634817 succinate
BP15173	PF-0463481 succinate is a potent and orally active dual antagonist of CCR2/CCR5 with comparable human and rodent CCR2 potency with IC50 of 20.8 nM.
BP15174	Zimlovisertib
BP15174	PF06650833 is an effective, selective and orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) (IC50s: 0.2 and 2.4 nM in the cell and PBMC assay).
BP15175	Phenylbutazone
BP15175	Phenylbutazone is a butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ankylosing spondylitis, rheumatoid arthritis, and reactive arthritis.
BP15176	Picein
BP15176	Picein is derived from Picrorhiza kurroa and shows antioxidant properties.
BP15177	Plumbagin
BP15177	Plumbagin is a yellow dye, formally derived from naphthoquinone. It is named after the plant genus Plumbago, from which it was originally isolated. It is also commonly found in the carnivorous plant genera Drosera and Nepenthes. It is also a component of the black walnut drupe.
BP15178	PMX 205 acetate(514814-49-4 free base)
BP15178	PMX 205 acetate is an antagonist of complement C5a receptor (C5aR; CD88).
BP15179	PTIO
BP15179	PTIO is a specific scavenger of NO. PTIO reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. PTIO can be used to examine nitric oxide synthase inhibitory activity.
BP15180	Pyrazoloadenine
BP15180	Pyrazoloadenine is the inhibitor of human xanthine oxidase.
BP15181	Quercetin-3-O-glucose-6''-acetate
BP15181	Quercetin-3-O-glucose-6''-acetate is an inhibitor of NADPH oxidase. Quercetin-3-O-glucose-6''-acetate has antioxidant activities.