Autophagy

Autophagy is an intracellular catabolic mechanism. In certain stressful situations, lysosomes degrade degenerated, damaged, aged or non-functional cells, organelles and biomolecules such as proteins and nucleic acids to achieve cellular protection and organelles from cell damage. Autophagy is achieved by forming a bilayer membrane structure in the cytoplasm that wraps the material to be removed and transports it to the lysosome for degradation. In multicellular organisms, newly formed autophagic vesicles form autophagic endosomes by fusing with vesicles in different stages of the endocytic lysosomal pathway, such as early endosomes and late endosomes, before fusing with lysosomes, a process known as autophagic vesicle maturation. Abnormalities in autophagosome maturation, which is precisely regulated by cellular trophic state and stress signaling pathways, lead to the accumulation of large amounts of damaged organelles and toxic protein aggregates in cells.

Cat. No.	Product name
BP12598	GW406108X(Z/E)
BP12598	GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1.
BP12599	Reparixin
BP12599	Reparixin is a potent inhibitor of both CXCL8 receptors CXCR1/2, it inhibits weakly CXCR2-mediated cell migration (IC50=100 nM), whereas it strongly blocks CXCR1-mediated chemotaxis (IC50=1 nM).
BP12600	Reparixin L-lysine salt
BP12600	Reparixin L-lysine salt is an allosteric chemokine receptor 1/2 (CXCR1/2) activation inhibitor.
BP12601	Penfluridol
BP12601	Penfluridol is a highly potent antipsychotic.
BP12602	SD 0006
BP12602	SD 0006 is a MAPK p38 alpha inhibitor( IC50 : 110 nM) for the treatment of arthritis.
BP12603	Gambogic Acid
BP12603	Gambogic Acid ( EC50=0.78-1.64 uM) activates caspases. Gambogic Acid competitively suppresses Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1. The IC50s of Gambogic Acid for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 uM, respectively.
BP12604	NH125
BP12604	NH125 is a selective eEF-2 kinase inhibitor with IC50 of 60 nM, >125-fold selectivity over PKC, PKA, and CaMKII, and also a potent histidine kinase inhibitor.
BP12605	GW 4064
BP12605	GW 4064 is an effective farnesoid X receptor (FXR) agonist (EC50 =65 nM).
BP12606	SB 216763
BP12606	SB216763 is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).
BP12607	Oxidopamine hydrochloride
BP12607	Oxidopamine hydrochloride is an neurotransmitter dopamine antagonist.
BP12608	Doramapimod
BP12608	Doramapimod is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.
BP12609	CCG-1423
BP12609	CCG-1423, a selective RhoA pathway inhibitor, suppresses SRF-mediated transcription.
BP12610	Rosuvastatin
BP12610	Rosuvastatin is an antilipemic agent that competitively inhibits hydroxymethyl-glutaryl-coenzyme A (HMG-CoA) reductase. HMG-CoA reductase catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Rosuvastatin belongs to a class of medications called statins and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
BP12611	Glucosamine sulfate
BP12611	Extracted from synthetic product;Store the product in sealed, cool and dry condition
BP12612	Oxyresveratrol
BP12612	Oxyresveratro can inhibit tyrosinase activity. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. Oxyresveratrol has antioxidant activity, can reduce neuronal oxidative damage and protect hepatocytes against oxidative stress and mitochondrial dysfunction, which may be associated with activation of Nrf2.
BP12613	Carbamazepine
BP12613	Carbamazepine is a tricyclic compound chemically related to tricyclic antidepressants (TCA) with anticonvulsant and analgesic properties. Carbamazepine exerts its anticonvulsant activity by reducing polysynaptic responses and blocking post-tetanic potentiation. Its analgesic activity is not understood; however, carbamazepine is commonly used to treat pain associated with trigeminal neuralgia.
BP12614	Retinoic acid
BP12614	Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. Tretinoin is a naturally-occurring acid of retinol. The oral form of tretinoin has teratogenic and embryotoxic properties.
BP12615	Clinofibrate
BP12615	Clinofibrate（IC50 of 0.47 mM）, a lipid-lowering agent, inhibits hydroxymethylglutaryl coenzyme A reductase (HMGCR). It is utilized to control high cholesterol and triacylglyceride levels in the blood.
BP12616	L-779450
BP12616	L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM), displays > 7, > 30 and > 70-fold selectivity over p38α, GSK3β and Lck respectively.
BP12617	Dynasore
BP12617	Dynasore, a cell-permeable chemical, can reversibly and non-competitivity inhibit GTPase activity of dynamin 1/2 (IC50: 15 μM in a cell-free assay). It also inhibits the mitochondrial dynamin Drp1, with no effect against other small GTPase.