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BP16121
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PF 03716556
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PF 3716556, an effective and specific P-CAB (potassium-competitive acid blocker), is utilized for the treatment of gastroesophageal reflux disease.
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BP16122
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PF 05089771 tosylate
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PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50: 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50: 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50: ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50: 10/20 μM). PF-05089771 is also 1, 000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation of the domain IV voltage-sensor domain (VSD4) reduces PF-05089771 potency by approximately 100-fold.
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BP16123
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PF-05186462
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PF-05186462 is a potent, state-dependent, subtype selective Nav1.7 inhibitor with IC50 of 21 nM, no significant activity against Nav1.5.
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BP16124
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Phellamurin
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Phellamurin inhibits intestinal P-glycoprotein in a dose-dependent manner, there is a serious interaction occurred between Phellamurin with cyclosporin, to ensure the efficacy of cyclosporin, we suggest that the coadministration of Phellamurin or Phellodendron wilsonii with cyclosporin should be avoided.
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BP16125
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Phe-Met-Arg-Phe, amide acetate
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Phe-Met-Arg-Phe, amide acetate dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.
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BP16126
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Phenazopyridine hydrochloride
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Phenazopyridine Hydrochloride is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red blood cells (methemoglobinemia), hemolytic anemia as well as renal and hepatic toxicity. It is reasonably anticipated to be a human carcinogen.
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BP16127
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Phenibut
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Phenibut is a central depressant and derivative of the naturally occurring inhibitory neurotransmitter γ-aminobutyric acid (GABA).
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BP16128
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Pilsicainide HCl
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Pilsicainide HCl is a pure sodium channel blocker
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BP16129
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Pinacidil monohydrate
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Pinacidil monohydrate is a potassium channel activator, antihypertensive drug.
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BP16130
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Pinaverium bromide
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Pinaverium bromide is an calcium channel blocker with Antispasmodic and effectively relieves pain, diarrhea and intestinal discomfort.
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BP16131
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Pivagabine
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Pivagabine is a derivative of hydrophobic 4-aminobutyric acid, with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.
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BP16132
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Potassium Channel Activator 1
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Potassium Channel Activator 1 can be used in studies about the treatment of disorders or conditions wherein the dopaminergic system is disrupted such as mood disorders ADHD, schizophrenia, and other psychotic states.
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BP16133
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NBQX
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Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo.
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BP16134
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Prilocaine hydrochloride
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Prilocaine hydrochloride is a local anesthetic of the amino amide type, binds to voltage-gated sodium ion channels in the neuronal membrane, thereby preventing the permeability of sodium ions.
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BP16135
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Primidone
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Primidone is an anticonvulsant of the pyrimidinedione class.
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BP16136
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Procyclidine hydrochloride
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Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.
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BP16137
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Progabide
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Progabide is an agonist of the gamma-aminobutyric acid receptor.
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BP16138
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Propoxycaine hydrochloride
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Propoxycaine hydrochloride is an inhibit of voltage-gated sodium channels.
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BP16139
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PSB-12062
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PSB-12062 is a potent and selective antagonist of P2X4(IC50 of 1.38 μM for human P2X4).
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BP16140
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p-Tolylmaleimide
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p-Tolylmaleimide is an inhibitor of the water channel and binds to Aquaporin Z.
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