Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP14215	SS-208
BP14215	SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
BP14214	SRT3657
BP14214	SRT3657 is a brain-permeable SIRT1 activator, has neuroprotective effect.
BP14213	SRT 2104
BP14213	SRT2104 (GSK2245840) is a selective and brain-permeable SIRT1 activator.
BP14212	SRT 1460
BP14212	SRT1460 is a SIRT1 activator.
BP14211	SRT1720 hydrochloride
BP14211	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2/SIRT3 (EC1.5s: 37 μM/300 μM).
BP14210	SRT 1720 dihydrochloride[925434-55-5(free base)]
BP14210	SRT 1720 is a selective activator of SIRT1 (EC1.5: 0.16 μM) and shows less potent activities on SIRT2 (EC1.5: 37 μM) and SIRT3 (EC1.5: 300 μM).
BP14209	COH-SR4
BP14209	SR4 is a uncoupler of mitochondrial oxidative phosphorylation. SR4 modulating amp-dependent kinase (ampk)-mammalian target of rapamycin (mtor) signaling, and inhibiting proliferation of hepg2 hepatocarcinoma cells
BP14208	SR-4370
BP14208	SR- 4370 is an HDAC inhibitor. SR- 4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR- 4370 is reported in WO 2015153516.
BP14207	Splitomicin
BP14207	Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
BP14206	Sotrastaurin
BP14206	Sotrastaurin is a potent pan-PKC inhibitor (Kis: 0.95/0.64/2.1/3.2/1.8/0.22 nM for PKCα/βI/δ/ε/η/θ).
BP14205	Aurothiomalate sodium
BP14205	Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium exhibits potent anti-tumor activity.
BP14204	SNDX-5613
BP14204	SNDX-5613 is a potent and specific inhibitor of Menin-MLL(Ki of 0.149 nM and a cell based IC50 of 10-20 nM). SNDX-5613 can be used for the research of MLL-rearranged (MLL-r) acute leukemias.
BP14203	SMYD3-IN-1
BP14203	SMYD3-IN-1 is an irreversible and selective SMYD3 (SET and MYND domain containing 3) inhibitor(IC50 of 11.7 nM).
BP14202	SMYD2-IN-1
BP14202	SMYD2-IN-1 is an inhibitor of SMYD2 (IC50 of 4.45 nM).
BP14201	SMARCA-BD ligand 1 for Protac
BP14201	SMARCA-BD ligand 1 for Protac is a compound capable of binding to SMARCA2, the BAF ATPase subunit, based on the Protac technology for degrading SMARCA2
BP14200	SMARCA-BD ligand 1 for Protac dihydrochloride
BP14200	SMARCA-BD ligand 1 for Protac dihydrochloride binds to the BAF ATPase subunits SMARCA2, and used for degrading SMARCA2, based on PROTAC.
BP14199	SKLB-23bb
BP14199	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
BP14198	SIS17
BP14198	SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
BP14197	Sirtuin modulator 1
BP14197	Sirtuin modulator 1 is a modulator of SIRT1 with EC1.5 of < 1 μM.
BP14196	SIRT-IN-2
BP14196	SIRT-IN-2 is a potent SIRT1/2/3 inhibitor(IC50s of 4, 1, 7 μM, respectively).