Purdue Bioscience - SpeciPure

SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 198
4 mg	In stock	$ 356
8 mg	In stock	$ 601
20 mg	In stock	$ 1099
40 mg	In stock	$ 1736

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
Targets&IC50	HDAC6:17 nM
In vivo	In vivo efficacy evaluations of colorectal HCT116, acute myelocytic leukemia MV4-11, and B cell lymphoma Romas xenografts, SKLB-23bb more effectively inhibited the tumor growth than SAHA even at a 4-fold reduced dose or ACY-1215 at the same dose. SKLB-23bb is a potent oral anticancer candidate for selective HDAC6 inhibitor.
CAS No.	1815580-06-3
Chemical Formula	C21H24N4O4
Molecular Weight	396.447
Solubility	DMSO: 32 mg/mL (80.72 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

SKLB-23bb

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