Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP13615	[Ala107]-MBP (104-118) acetate
BP13615	[Ala107]-MBP (104-118) acetate is synthetic peptide analog of bovine myelin basic protein (MBP). Non-competitive inhibitor of PKC (IC50 = 46 - 145 mM).
BP13614	(Z)-SMI-4a
BP13614	(Z)-SMI-4a is a selective ATP-competitive Pim-1 kinase inhibitor with an IC50 of 21 nM.
BP13613	(Z)-Butylidenephthalide
BP13613	(Z)-Butylidenephthalide has antitumor effect, can effectively inhibit the tumor growth in the glioma.
BP13612	(S)-GNE-987
BP13612	(S)-GNE-987 binds to the BRD4 BD1(IC50=4 nM) and BD2 (3.9 nM) bromodomains and can be used to design PROTAC-Antibody Conjugate (PAC).
BP13611	(rel)-Tranylcypromine D5 hydrochloride
BP13611	(rel)-Tranylcypromine D5 hydrochloride is a deuterium labeled (rel)-Tranylcypromine hydrochloride. (rel)-Tranylcypromine hydrochloride is an irreversible, nonselective inhibitor of monoamine oxidase (MAO) used in the treatment of depression.
BP13610	(Rac)-BAY1238097
BP13610	(Rac)-BAY1238097 is a inhibitor of BET(IC50 of 1.02 μM for BRD4),used in cancer research.
BP13609	(R)-UT-155
BP13609	(R)-UT-155 is a selective androgen receptor degrader (SARD) ligand.
BP13608	(R)-(-)-JQ1 Enantiomer
BP13608	(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
BP13607	(2R,3S)-Dihydrodehydroconiferyl alcohol
BP13607	(2R,3S)-Dihydrodehydroconiferyl alcohol can induce neurite outgrowth and enhance NGF-induced neurite outgrowth from PC12 cells by amplifying up-stream steps such as MAPK and PKC.
BP13606	(2R)-Octyl-α-hydroxyglutarate
BP13606	(2R)-Octyl-α-hydroxyglutarate ((2R)-Octyl-2-HG) is a D-isomer 2-Hydroxyglutarate modified form.
BP13605	(±)-1,2-Diolein
BP13605	(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein increases myotubes Ca 2+ influx .
BP13604	(+)-Syringaresinol
BP13604	(+)-Syringaresinol shows antioxidant potential, it exhibits cytoprotective activity in cultured MCF-7 cells stressed by H2O2.
BP13603	(+)-JQ1 PA
BP13603	(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM.
BP13602	(-)-Indolactam V
BP13602	(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2, γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B). It has antitumor activity.