Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP13837	EX229
BP13837	EX229 is an allosteric activator of AMPK, with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1, and α1β2γ1, respectively.
BP13836	Selisistat
BP13836	EX 527 is an effective and specific SIRT1 inhibitor (IC50: 38 nM) and shows >200-fold selectivity against SIRT2/3.
BP13835	Euxanthone
BP13835	Euxanthone has vasorelaxation effect, may be through multiple pathways involved PKC-mediated signal pathway and calcium-independent pathway, it induces its vasodilator effect through inhibition of calcium-sensitive mechanisms activated by protein kinase C. Euxanthone-induced neurite outgrowth was actively regulated by transcription factor E2F-5 via PKC pathway, it-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms.
BP13834	Euphorbiasteroid
BP13834	Euphorbiasteroid (25-50 μM) decreased differentiation of 3T3-L1 cells via reduction of intracellular triglyceride (TG) accumulation.
BP13833	Euchrestaflavanone B
BP13833	Euchrestaflavanone B shows antibacterial activity against Gram positive bacteria, Staphylococcus aureus, Bacillus subtilis and Bacillus cereus. Euchrestaflavanone B may function by inhibiting oncogenic disease, at least in part, through the inhibition of protein kinase CKII activity.
BP13832	Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate
BP13832	Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
BP13831	Bempedoic acid
BP13831	ETC-1002, also known as ESP-55016 and Bempedoic acid, is an orally available, once-daily LDL-C lowering small molecule designed to lower elevated levels of LDL-C and to avoid side effects associated with existing LDL-C lowering therapies. Bempedoic acid is absorbed rapidly in the small intestine and enters the liver through cell surface receptors different from those transporters that selectively take up statins. Bempedoic acid is a regulator of lipid and carbohydrate metabolism.
BP13830	Et-29
BP13830	Et-29 is a selective inhibitor of SIRT5 inhibitor with a Ki of 40 nM.
BP13829	EPZ031686
BP13829	EPZ031686 is an effective inhibitor of SMYD3 inhibitor with an IC50 of 3 nM and can be used in studies about cancer.
BP13828	EPZ020411
BP13828	EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).
BP13827	EPZ020411 hydrochloride
BP13827	EPZ020411 is a selective and potent small molecule PRMT6 inhibitor with an IC50 value of 10 nM.
BP13826	EPZ015666
BP13826	EPZ015666 is an orally available inhibitor of PRMT5 enzymatic activity.
BP13825	EPZ011989
BP13825	EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki 3000-fold selectivity over other HMTase.
BP13824	EPZ005687
BP13824	EPZ005687 is a potent and selective inhibitor of EZH2.
BP13823	ENMD-1198
BP13823	ENMD-119 is a 2-methoxyestradiol analog with antiproliferative and antiangiogenic activity. It is suitable for inhibiting HIF-1α and STAT3 in human HCC cells.
BP13822	Enarodustat
BP13822	Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
BP13821	EML741
BP13821	EML741 also inhibits DNMT1 (IC50, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated. EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC50 of 23 nM, Kd of 1.13 μM for G9a.
BP13820	EML 425
BP13820	EML 425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
BP13819	Elevenostat
BP13819	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
BP13818	EI1
BP13818	EI1 is a potent and selective EZH2 inhibitor with IC50 of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.