Purdue Bioscience - SpeciPure

Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 77
4 mg	In stock	$ 138
8 mg	In stock	$ 220
20 mg	In stock	$ 403
40 mg	In stock	$ 624

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Description	Enarodustat is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
Targets&IC50	factor prolyl hydroxylase:（EC50）0.22 μM
In vitro	Enarodustat exhibits neither CYP (IC50 > 100 μM; CYP3A4/5, CYP2C9, CYP2D6, CYP1A2, CYP2A6, CYP2C19, CYP2C8, CYP2B6) nor hERG (IC50 > 100 μM) inhibition.
In vivo	Enarodustat (1 and 3 mg/kg, p.o., in rats) treatment increases hemoglobin levels in a dose-dependent manner.
Synonyms	JTZ-951
CAS No.	1262132-81-9
Chemical Formula	C17H16N4O4
Molecular Weight	340.339
Solubility	DMSO: 83.33 mg/mL (244.85 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Enarodustat

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