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Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 173
2 mg	In stock	$ 328
4 mg	In stock	$ 524
10 mg	In stock	$ 959
20 mg	In stock	$ 1457

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Description	Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate is a selective inhibitor of histone methyltransferase SETD7 (IC50 = 4.59 μM) with anticancer activity.
In vitro	Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate (0-100 μM) inhibits the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner with the IC50 values of 10.93 μM and 16.43 μM, respectively. Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, whereas it inhibits SET7 by 90% at concentrations of 100 μM.
CAS No.	303141-21-1
Chemical Formula	C15H15N3O5S
Molecular Weight	349.36
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Ethyl 2-amino-4-methyl-5-[(3-nitrophenyl)carbamoyl]thiophene-3-carboxylate

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