Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP14075	OG-L002
BP14075	OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
BP14074	OF-1
BP14074	OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
BP14073	Oclacitinib
BP14073	Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM).
BP14072	O-304
BP14072	O-304 is a pan-activator of AMP-activated protein kinase (AMPK).
BP14071	NU1025
BP14071	NU1025 is a potent PARP inhibitor with IC50 of 400 nM.
BP14070	NSC 3852
BP14070	NSC 3852 is a potent inhibitor of histone deacetylase.
BP14069	NP213
BP14069	NP213 is a rapidly acting synthetic antimicrobial peptide (AMP). NP213 is effective and well-tolerated in resolving nail fungal infections. NP213 has anti-fungal activities. NP213 targets the fungal cytoplasmic membrane and plays its role via membrane perturbation and disruption.
BP13624	Nootkatone
BP13624	Nootkatone can provide effective tick control. (+)-Nootkatone has antiallergic, anti-inflammatory, and antiplatelet activities. Nootkatone can prevent obesity and improve physical performance through AMPK activation in skeletal muscle and liver.
BP14068	NMS-P118
BP14068	NMS-P118 is a potent, selective and orally available Inhibitor of PARP-1 for cancer therapy.
BP14067	Niraparib tosylate monohyrate
BP14067	Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base-excision repair (BER) pathway.
BP14066	Niraparib (R-enantiomer)
BP14066	Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).
BP14065	Nicotinamide riboside
BP14065	Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities.
BP14064	Nicotinamide riboside chloride
BP14064	Nicotinamide riboside chloride, also known as NR and SRT647, is a pyridine-nucleoside form of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide or NAD+.
BP14063	Nicotinamide
BP14063	Niacinamide is an important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
BP14062	NI-57
BP14062	NI-57 is an inhibitor of proteins of bromodomain and plant homeodomain finger-containing (BRPF) family, with IC50s of 3.1, 46 and 140 nM for BRPF1, BRPF2 (BRD1) and BRPF3, respectively.
BP14061	NI-42
BP14061	NI-42 is a structurally orthogonal chemical probe for the BRPFs and is biased. It effective inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM). It also has excellent selectivity over nonclass IV BRD proteins.
BP14060	Nexturastat A
BP14060	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
BP14059	Neuropathiazol
BP14059	Neuropathiazol is a synthetic small molecule. It also causes neuronal differentiation of adult hippocampal neural progenitor cells.
BP14058	Neurodazine
BP14058	Neurodazine is an imidazole-based small molecule, serves as a promoter of neurogenesisin pluripotent cells. Neurodazine selectively inhibits astrocyte differentiation of P19 cells. Neurodazine promotes neurogenesis by activating Wnt and Shh signaling pathways.
BP14057	Nepodin
BP14057	Nepodin has antimalarial, and anti-inflammatory activities, it shows significant cyclooxygenase (COX) inhibitory activity. Nepodin has an antidiabetic effect, which is at least partly mediated by stimulation of GLUT4 translocation via AMPK activation by nepodin.