Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP14056	NEO2734
BP14056	NEO2734 is an orally active and selective inhibitor of p300/CBP and BET bromodomain(IC50 of <30 nM for both p300/CBP and BET bromodomains).
BP14055	N-Desmethyltamoxifen hydrochloride
BP14055	N-Desmethyltamoxifen hydrochloride is the major tamoxifen metabolite in humans.
BP14054	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine
BP14054	N-Cyclohexyl-4-[1-(1-piperazinyl)-2,6-naphthyridin-3-yl]-2-pyridinamine is a novel 2,6-naphthyridine identified by high throughput screen (HTS) as a dual protein kinase C/D (PKC/PKD) inhibitor.
BP14053	NCGC00244536
BP14053	NCGC00244536 is a potent KDM4B inhibitor (IC50: 10 nM).
BP14052	N-Caffeoyltryptophan
BP14052	N-Caffeoyltryptophan, a potential Sirt inhibitor, is screened using coffee extract. N-Caffeoyltryptophan inhibited Sirt2 (IC50; 8.7 μM) better than Sirt1(IC50; 34μM).
BP14051	Naphthol AS-E
BP14051	nAS-E is an the KIX-KID interaction and CREB-mediated gene transcription inhibitor.
BP14050	Nanaomycin A
BP14050	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).
BP14049	N-[(4-Aminophenyl)methyl]adenosine
BP14049	N-[(4-Aminophenyl)methyl]adenosine is an adenosine receptor inhibitor (Ki: 29 nM for Rat ecto-5′-Nucleotidase).
BP14048	MZP-55
BP14048	MZP-55 is a selective BRD3/4 degrader based on PROTAC technology(Brd4BD2 with Kd of 8 nM)
BP14047	MZP-54
BP14047	MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)
BP14046	MZ 1
BP14046	MZ 1 is a BRD4 protein degrader based on PROTAC technology.
BP14045	Myricitrin
BP14045	Myricitrin, a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
BP14044	Myricetin 3-O-galactoside
BP14044	Myricetin 3-O-galactoside has cytotoxicity, antioxidant, anti-genotoxic, antinociceptive and anti-inflammatory effects, the effects are related to peripheral inhibition of nitric oxide synthesis, mainly inducible nitric oxide synthase (iNOS).
BP14043	MS7972
BP14043	MS7972 is CREBBP inhibitor that blocks human p53 and CREB binding protein association. MS7972 can almost completely block this BRD interaction at 50 μM
BP14042	MS645
BP14042	MS645 is an inhibitor of bromodomain-containing protein 4 (BRD4) with a Ki of 18.4 nM for BRD4-BD1/BD2.
BP14041	MS436
BP14041	MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
BP14040	MS417
BP14040	MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP BRD with IC50 of 32.7 μM.
BP14039	MS402
BP14039	MS402 is a novel BD1-selective BET BrD inhibitor.
BP14038	MS31 trihydrochloride (2366264-12-0 free base)
BP14038	MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor.
BP14037	MS023
BP14037	MS023 is a potent, selective, and cell-active Type I PRMT inhibitor with IC50 of 30 nM, 119 nM, 83 nM, 4 nM, and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively.