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BP14115
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PJ34
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PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2.
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BP14114
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Pimelic diphenylamide 106
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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM, 760 nM and 370 nM for HDAC 1, 2, and 3, respectively), showing no activity against class II HDACs.
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BP14113
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PIM1-IN-1
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PIM1-IN-1 is a potent and highly selective inhibitor of PIM1/3(IC50s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively),with Antiproliferative and anti-cancer activity.
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BP14112
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Pim1/AKK1-IN-1
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Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
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BP14111
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SMI-16a
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PIM1/2 Kinase Inhibitor VI, a cell-permeable thiazolidinedione compound, acts as an effective, ATP-competitive inhibitor against Pim-1/2 kinases (IC50: 150/20 nM) while exhibiting little or no activity against a panel of 57 other kinases (≤18% inhibition at 5 μM).
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BP14110
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Picolinamide
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Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.
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BP14109
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Phorbol
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Phorbol, a plant-derived diterpene, is a tumor promoter through the activation of protein kinase C.
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BP14108
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Phorbol 12-myristate 13-acetate
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Phorbol 12-myristate 13-acetate (PMA) is a dual SphK and PKC activator.
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BP14107
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Phorbol 12,13-dibutyrate
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Phorbol 12,13-dibutyrate is a PKC activator. It also is a potent skin tumor promoter.
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BP14106
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Phillyrin
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Phillyrin is a novel AMPK activator, has anti-obesity effects in nutritive obesity mice, it can prevent lipid accumulation in HepG2 cells by blocking the expression of SREBP-1c and FAS through LKB1/AMPK activation. Phillyrin may be a new preventive agent of acute lung injury in the clinical setting, it potentially contributes to the suppression of the activation of MAPK and NF-κB pathways, it also has protective effects on H2O2-induced oxidative stress and apoptosis in PC12 cells.
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BP14105
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Phenylethyl isothiocyanate
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Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.
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BP14104
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PHD-1-IN-1
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PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
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BP14103
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PFI-4
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PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
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BP14102
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PFI-3
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PFI-3 is a selective chemical inhibitor for SMARCA (2/4) (Kd = 89 nM)and PBI (5) bromodomains which may result in the delay and prevention of breast cancer.
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BP14101
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PFI-2
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PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.
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BP14100
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PF-CBP1 hydrochloride
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PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
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BP14099
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PF-CBP1
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PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 363 nM).
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BP14098
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PF-9363
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PF-9363 is a potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer.
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BP14097
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PF-249
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PF-249 is a β1-selective AMPK with an EC50 of 12 nM for AMPK α1β1γ1 and can be used in studies about diabetic nephropathy.
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BP14096
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PF-06821497
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PF-06821497 is a selective inhibitor of EZH2 with significant tumor growth inhibition.
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