BP13529
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TCID
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TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.
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BP13530
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TC-S 7005
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TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively.
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BP13531
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Tegafur
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Tegafur (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.
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BP13532
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Tempo
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Tempo is a classic nitroxide radical and is a selective scavenger of ROS that dismutases superoxide in the catalytic cycle. Tempo induces DNA-strand breakage. Tempo can be used as an organocatalyst for the oxidation of primary alcohols to aldehydes. Tempo has mutagenic and antioxidant effects.
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BP13533
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TH-257
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TH 257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM).
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BP13534
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TH287
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TH287 is a potent inhibitor of MTH1 (NUDT1), less potent for MTH2, NUDT5, NUDT12, NUDT14, and NUDT16.
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BP13535
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TH287 hydrochloride
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TH287 is a selective MTH1 inhibitor(IC50 : 0.8 nM). It causees incorporation of oxidized dNTPs in cancer cells, leading to DNA damage, cytotoxicity and therapeutic responses in patient-derived mouse xenografts.
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BP13536
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TH588
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TH588 is nudix hydrolase family inhibitor that effectively and selectively engages and inhibits the MTH1(IC50: 5 nM) in cells.
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BP13537
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THAL-SNS-032
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THAL-SNS-032 is a selective CDK9 degrader PROTAC.
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BP13538
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Thiarabine
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Thiarabine displays effective anti-tumor activity. It also inhibition of DNA synthesis.
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BP13539
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Thiazovivin
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Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
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BP13540
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Thiostrepton
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Thiostrepton is a one of the CYCLIC PEPTIDES from Streptomyces that is active against gram-positive bacteria. In veterinary medicine, it has been used in mastitis caused by gram-negative organisms and in dermatologic disorders.
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BP13541
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THZ1 2HCl
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THZ1 2HCl is a selective, covalent, and allosteric inhibitor of CDK7 with an IC50 of 3.2 nM. THZ1 2HCl has antiproliferative effects on a variety of cancer cell lines.
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BP13542
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THZ1
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THZ1 is a novel selective and potent covalent CDK7 inhibitor.
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BP13543
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THZ1-R
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THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM).
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BP13544
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THZ2
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THZ2, an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).
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BP13545
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THZ531
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THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).
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BP13546
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Tipiracil hydrochloride
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Tipiralacil is a thymidine phosphorylase inhibitor (TPI). Tipiracil is one of the active components in TAS-102, which is an anticancer drug candidate currently in clinical trials.
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BP13547
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TK216
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TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.
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BP13548
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TMPyP4 tosylate
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TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.
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