Purdue Bioscience - SpeciPure

TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 67
4 mg	In stock	$ 113
8 mg	In stock	$ 169
20 mg	In stock	$ 366
40 mg	In stock	$ 556

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC50 of 0.6 μM. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.
Targets&IC50	UCH-L3:0.6 μM
In vitro	TCID (4,5,6,7-Tetrachloroindan-1,3-dione; compound 11) inhibits UCH-L1 with an IC50 of 75 μM. TCID (10 μM; 1, 2 hours) diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons.
Synonyms	UCH-L3 Inhibitor
CAS No.	30675-13-9
Chemical Formula	C9H2Cl4O2
Molecular Weight	283.91
Solubility	DMSO: 100 mg/mL (296.45 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

TCID

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In vivo Formulation Calculator (Clear solution)

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