Purdue Bioscience - SpeciPure

WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).

Pack Size	Availability	Price/USD
5 mg	In stock	$ 370
10 mg	In stock	$ 666
20 mg	In stock	$ 999
50 mg	In stock	$ 2203
100 mg	In stock	$ 3480

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I).
Targets&IC50	Calu-3 (ERBB2 amp): 915 nM , H3255 (EGFR L858R): 66 nM, H1975 (EGFR L858R/T790M): 9 nM, HCC827 GR (EGFR E746_A750/MET amp): >3.3 μM, H1781 (ERBB2 Ins G776V, C): 744 nM , PC9 (EGFR Del E746_A750): 6 nM, PC9 GR (EGFR Del E746_A750/T790M): 8 nM, H1819 (ERBB2 amp): 738 nM , HCC827 (EGFR Del E746_A750): 1 nM
In vitro	Cells are exposed to increasing concentrations of WZ8040 for 72 hours. Growth is assessed using the MTS survival assay.(Only for Reference)
CAS No.	1214265-57-2
Chemical Formula	C24H25ClN6OS
Molecular Weight	481.02
Solubility	H2O: <1 mg/mL Ethanol: 3 mg/mL (6.23 mM); DMSO: 89 mg/mL (185 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

WZ8040

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In vivo Formulation Calculator (Clear solution)

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Molarity Calculator allows you to calculate the

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