Ionomycin is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 200 | |
| 5 mg | In stock | $ 900 | |
| 10 mg | In stock | $ 1400 |
| Description | Ionomycin is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC). |
| In vitro | Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus.Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment.Ionomycin also phosphorylate p38 MAPK by Ca2+ influx through SOCE, leading to suppression of TNF-α-induced NF-κB phosphorylation. |
| CAS No. | 56092-81-0 |
| Chemical Formula | C41H72O9 |
| Molecular Weight | 709.01 |
| Solubility | DMSO: 100 mg/mL (141.04 mM, Need ultrasonic) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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