WHI-P154 is a potent JAK3 inhibitor.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 2 mg | In stock | $ 92 | |
| 4 mg | In stock | $ 156 | |
| 8 mg | In stock | $ 261 | |
| 20 mg | In stock | $ 533 | |
| 40 mg | In stock | $ 815 |
| Description | WHI-P154 is a potent JAK3 inhibitor. |
| Targets&IC50 | EGFR: 4 nM, VEGFR: 100 nM, JAK3: 1.8 μM, Src: 100 nM |
| In vitro | Cells are seeded into a 96-well plate at a density of 2.5×104 cells/well and incubated for 36 h at 37 ℃ before drug exposure. On the day of treatment, culture medium is carefully aspirated from the wells and replaced with fresh medium containing the quinazoline compounds WHI-P154 at concentrations ranging from 0.1 μM to 250 μM. Triplicate wells are used for each treatment. The cells are incubated with the compound for 24hours to 36hours at 37 ℃ in a humidified 5% CO2 atmosphere. To each well, 10 μL of MTT (final concentration, 0.5 mg/mL) is added, and the plate are incubated at 37 ℃ for 4 h. Than solubilized overnight at 37 ℃ in a solution containing 10% SDS in 0.01 M HCL. The absorbance of each well is measured in a microplate reader at 570 nm.(Only for Reference) |
| Synonyms | Jak3 inhibitor ii |
| CAS No. | 211555-04-3 |
| Chemical Formula | C16H14BrN3O3 |
| Molecular Weight | 376.21 |
| Solubility | DMSO: 37.6 mg/mL (100 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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