Purdue Bioscience - SpeciPure

TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.

Pack Size	Availability	Price/USD
1 mg	2-3 weeks	$ 201
2 mg	2-3 weeks	$ 381
4 mg	2-3 weeks	$ 571
10 mg	2-3 weeks	$ 1051
20 mg	2-3 weeks	$ 1608

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.
Targets&IC50	JAK2: 2.55 μM, PKCα: 13 nM, JAK1: 1.017 μM, PKCθ: 68 nM, JAK3: 8 nM, GSK-3β: 3 nM
Synonyms	NIBR3049
CAS No.	1260181-14-3
Chemical Formula	C27H25F3N4O4
Molecular Weight	526.516
Solubility	DMSO: ≥ 53 mg/mL (129.13 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

TCS 21311

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