Purdue Bioscience - SpeciPure

TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.

Pack Size	Availability	Price/USD
2 mg	8-10 weeks	$ 94
4 mg	8-10 weeks	$ 178
8 mg	8-10 weeks	$ 238
20 mg	8-10 weeks	$ 435
40 mg	8-10 weeks	$ 656

Description	TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.
Targets&IC50	in K562 cells: 13.48 nM (GI50)
In vitro	Cells are seeded in 96 well plates, incubated for 24 hours, compounds added and incubated for 96 hours. All testing points are tested in triplicate wells. Cell viability is determined by MTS assay using CellTiter 96 Aqueous Non-radioactive Cell Proliferation Assay system according to manufacturer's instructions with MTS and PMS. Data retrieved from spectrophotometer are processed in Excel and GraphPad Prism 5 to calculate the concentration exhibiting 50% growth inhibition (GI50). All data represent the results of triplicate experiments.(Only for Reference)
Synonyms	TAI1, TAI 1
CAS No.	1334921-03-7
Chemical Formula	C24H21N3O3S
Molecular Weight	431.51
Solubility	DMSO: 80 mg/mL (185.4 mM) Ethanol: <1 mg/mL; H2O: <1 mg/mL
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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TAI-1

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