Purdue Bioscience - SpeciPure

PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.

Pack Size	Availability	Price/USD
5 mg	In stock	$ 110
10 mg	In stock	$ 198
20 mg	In stock	$ 299
50 mg	In stock	$ 560
100 mg	In stock	$ 845

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Description	PF-543 inhibits SphK1 with a K(i) of 3.6 nM, is sphingosine-competitive and is more than 100-fold selective for SphK1 over the SphK2 isoform.
Targets&IC50	sphingosine 1-phosphate (S1P): 26.7 nM (IC50), SphK1: 2 nM (IC50), SphK1: 3.6 nM (Ki)
Synonyms	PF-543
CAS No.	1706522-79-3
Chemical Formula	C27H32ClNO4S
Molecular Weight	502.07
Solubility	DMSO: 90 mg/mL (136.83mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

PF-543 hydrochloride

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In vivo Formulation Calculator (Clear solution)

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