NVP-BSK805 dihydrochloride is an effective and selective inhibitor of JAK2 with IC50s of 0.5 nM, 10.76 nM, 18.68 nM, and 31.63 nM for JAK2, TYK2, JAK3, and JAK1.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 120 | |
| 2 mg | In stock | $ 228 | |
| 4 mg | In stock | $ 306 | |
| 10 mg | In stock | $ 683 | |
| 20 mg | In stock | $ 1038 |
| Description | NVP-BSK805 dihydrochloride is an effective and selective inhibitor of JAK2 with IC50s of 0.5 nM, 10.76 nM, 18.68 nM, and 31.63 nM for JAK2, TYK2, JAK3, and JAK1. |
| Targets&IC50 | TYK2 (Cell-free assay): 10.76 nM, JAK2 (Cell-free assay): ~0.5 nM, JAK3 (Cell-free assay): 18.68 nM, JAK1 (Cell-free assay): 31.63 nM |
| In vitro | Cells can be detected by colorimetric assay kit WST-1 (Roche Diagnostics GmbH) The survival rate was used to analyze and compare the survival of cells after 72 hours of incubation with 8-point concentration range of drugs and the related changes in cell proliferation after treatment of cells with DMSO, which can detect the ability of JAK2 inhibitors to inhibit cell proliferation. After three repetitions, the mean value was calculated and plotted with XLfit 4 software to obtain the value of half of the maximum growth inhibition (GI50). |
| Synonyms | BSK805 |
| CAS No. | 1942919-79-0 |
| Chemical Formula | C27H30Cl2F2N6O |
| Molecular Weight | 563.47 |
| Solubility | DMSO: 40 mg/mL (71 mM), Need ultrasonic |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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