LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 2 mg | In stock | $ 103 | |
| 4 mg | In stock | $ 175 | |
| 8 mg | In stock | $ 296 | |
| 20 mg | In stock | $ 534 | |
| 40 mg | In stock | $ 849 |
| Description | LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met (Ki: 2 nM) with potential antineoplastic activity. LY2801653 selectively binds to c-Met, thereby inhibiting c-Met phosphorylation and disrupting c-Met signal transduction pathways. This may induce cell death in tumor cells overexpressing c-Met protein or expressing the constitutively activated c-Met protein. |
| Targets&IC50 | Met: 2 nM(Ki) |
| In vitro | 2×103 DU145 cells/well on poly-D-lysine 96-well black/clear plates are treated with LY2801653 (in 0.4 % DMSO), immediately followed by the addition of human HGF (20 ng/ml), and incubated for 48 h at 37 °C. 2 % formaldehyde fixed cells are stained with AlexaFluor 488 Phalloidin and counterstained with Propidium Iodide. Colony counts are quantified on Acumen Explorer laser-scanning fluorescence microplate cytometer. A colony is defined as≥4 cells.(Only for Reference) |
| Synonyms | LY2801653 |
| CAS No. | 1206799-15-6 |
| Chemical Formula | C30H22F2N6O3 |
| Molecular Weight | 552.542 |
| Solubility | H2O: <1 mg/mL Ethanol: 93 mg/mL (168.3 mM); DMSO: 93 mg/mL (168.3 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
In vivo Formulation Calculator (Clear solution)Calculatorbottom
