Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 10 mg | In stock | $ 72 | |
| 50 mg | In stock | $ 151 | |
| 100 mg | In stock | $ 268 | |
| 200 mg | In stock | $ 489 |
| Description | Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic. |
| Targets&IC50 | JNK; DNA synthesis |
| In vitro | To examine whether JNK has a core role in colistin-induced neurotoxicity in PC-12 cells, an SP600125 (a highly selective inhibitor of JNK) and Anisomycin (a potent activator) are used in this study. In order to select an appropriate concentration, PC-12 cells are treated with a range of SP600125 (0-80 μM) and Anisomycin (0-20 μM) respectively for 24 h. The results show that the cells viability significantly decreases by SP600125 treatment in a concentration-dependent manner, observed at the concentrations greater than 20 μM (p<0.01). Similarly the cells viability is inhibited by Anisomycin treatment (≥8 μM) (p<0.05) . |
| In vivo | Anisomycin (60 mg/kg; for 4-week continuous intravenous administration) significantly decreases mouse body weight in a dose-related manner, compared with the control group. Anisomycin (15 mg/kg; for 4-week continuous intravenous administration) slightly and transiently decreases the mouse body weight. There is no significant difference of the mouse body weight in 5 mg/kg group. |
| CAS No. | 22862-76-6 |
| Chemical Formula | C14H19NO4 |
| Molecular Weight | 265.31 |
| Solubility | DMSO: ≥ 50 mg/mL (188.46 mM) H2O: 4 mg/mL (15.08 mM, Need ultrasonic and warming and heat to 60°C) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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