Purdue Bioscience - SpeciPure

ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 102
2 mg	In stock	$ 193
4 mg	In stock	$ 276
10 mg	In stock	$ 563
20 mg	In stock	$ 867

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Description	ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
Synonyms	ADT-OH
CAS No.	18274-81-2
Chemical Formula	C9H6OS3
Molecular Weight	226.33
Solubility	DMSO: 10 mM
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Desmethylanethol trithione

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