DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 5 mg | In stock | $ 79 | |
| 10 mg | In stock | $ 150 | |
| 20 mg | In stock | $ 225 | |
| 50 mg | In stock | $ 405 | |
| 100 mg | In stock | $ 619 |
| Description | DBeQ(JRF-12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor. |
| Targets&IC50 | p97: 1.5 μM |
| In vitro | Cells are seeded on a 384-well solid white plate (5,000 cells/well). Cells are transfected with luciferase siRNA or p97 siRNA (10 nM) for 48 hours or treated with DBeQ for the indicated amount of time. Caspase-3/7 Glo, caspase-6 Glo, caspase-8 Glo, or caspase-9 Glo is added into each well and mixed by shaking at 500 rpm for 1 min. Luminescence signal is determined after incubation at room temperature for 1 hour. Cellular viability is determined with CellTiter-Glo reagen. To determine the IC50 of cellular viability, cells are treated with MG132 or DBeQ at seven concentrations (threefold serial dilutions starting at 33 μM) for 48 hours. IC50 values are calculated from tting the percentage of luminescence signal normalized to DMSO treated cells).(Only for Reference) |
| Synonyms | JRF 12 |
| CAS No. | 177355-84-9 |
| Chemical Formula | C22H20N4 |
| Molecular Weight | 340.43 |
| Solubility | DMSO: 34 mg/mL (100 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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