Purdue Bioscience - SpeciPure

CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 114
2 mg	In stock	$ 205
4 mg	In stock	$ 328
10 mg	In stock	$ 549
20 mg	In stock	$ 878

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Description	CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 μM) and inhibits NF-κB (EC50: 0.47 μM). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-κB and promoting cancer cell death. CBL0137 has broad anticancer activity in mice when administered orally, eradicates drug-resistant cancer stem cells, and potentiates the efficacy of gemcitabine in preClinicalal models of pancreatic cancer.
Targets&IC50	NF-κB: 0.47 μM (EC50), p53: 0.37 μM (EC50)
Synonyms	Curaxin 137, CBLC137
CAS No.	1197996-80-7
Chemical Formula	C21H24N2O2
Molecular Weight	336.435
Solubility	DMSO: ~5 mg/mL H2O: InsolubL; E
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

CBL0137

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In vivo Formulation Calculator (Clear solution)

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Molarity Calculator allows you to calculate the

Calculator the dilution required to prepare a stock solution

Calculate the volume of solvent required to reconstitute your vial.

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

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