Purdue Bioscience - SpeciPure

Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)

Pack Size	Availability	Price/USD
2 mg	In stock	$ 94
4 mg	In stock	$ 169
8 mg	In stock	$ 270
20 mg	In stock	$ 517
40 mg	In stock	$ 785

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Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Description	Cambinol is a cell-permeable b-naphthol compound that inhibits the NAD-dependent deacetylase activity of SIRT1/2 (IC50: 56/59 μM, respectively) in a substrate-, but not NAD-, competitive manner. Cambinol inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 μM) and no inhibitory for the class I and II HDACs. In BCL6-expressing Burkitt lymphoma cell lines, Cambinol-induced apoptosis has been attributed to the hyperacetylation of p53 and BCL6.Cambinol is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)
Targets&IC50	SIRT1: 56μM, SIRT2: 59 μM
Synonyms	SIRT1/2 Inhibitor IV, NSC 112546
CAS No.	14513-15-6
Chemical Formula	C21H16N2O2S
Molecular Weight	360.43
Solubility	Ethanol: 5 mg/mL DMSO: 10 mg/mL
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Cambinol

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