CEP-32496 is a highly potent inhibitor of BRAF.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 2 mg | In stock | $ 109 | |
| 4 mg | In stock | $ 207 | |
| 8 mg | In stock | $ 294 | |
| 20 mg | In stock | $ 523 | |
| 40 mg | In stock | $ 831 |
| Description | CEP-32496 is a highly potent inhibitor of BRAF. |
| Targets&IC50 | c-Kit: 2 nM(Kd), PDGFRβ: 2 nM(Kd), Abl1: 3 nM(Kd), Lck: 2 nM(Kd), RET: 2 nM(Kd) |
| In vitro | Cells are seeded at 104 cells per well in DMEM with 10% fetal calf serum and allowed to attach. The cells are washed with PBS and switched to DMEM with 0.5% of serum and incubated overnight. CEP-32496 is then added at various concentrations with a final DMSO concentration of 0.5% and incubated for 72 h. At the end of incubation, a Cell Titer Blue is added per instructions, and incubation is continued for 3 hours. Remaining viable cells are quantified by measuring the strength of the fluorescence signal using SoftMax Pro (excitation at 560 nm and emission at 590 nm). IC50 values are derived using a 9-point curve fitted with Igor Pro and are presented as mean values from experiments performed in duplicate. Variability between individual values is less than 2-fold.(Only for Reference) |
| Synonyms | CEP32496, CEP 32496, RXDX-105, CEP-32496 |
| CAS No. | 1188910-76-0 |
| Chemical Formula | C24H22F3N5O5 |
| Molecular Weight | 517.465 |
| Solubility | Ethanol: <1 mg/mL DMSO: 9 mg/mL (17.39 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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