Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 127 | |
| 2 mg | In stock | $ 228 | |
| 4 mg | In stock | $ 361 | |
| 10 mg | In stock | $ 615 | |
| 20 mg | In stock | $ 940 |
| Description | Micheliolide(MCL) is a sesquiterpene lactone which inhibits various inflammatory response. |
| In vitro | Treatment of BV2 cells with Micheliolide(MCL) significantly repressed LPS-stimulated nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression, as well as tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nitric oxide (NO) induction.?MCL also attenuated mRNA levels of multiple pro-inflammatory cytokines and mediators such as iNOS, COX-2, TNF-α, IL-6 and IL-1β.?Mechanistic studies revealed that MCL suppressed LPS-stimulated the activation of IκBα/NF-κB pathway and Akt pathway.?Moreover, MCL inhibited LPS-induced the activition of c-Jun N-terminal kinase (JNK), p38 MAPK kinase, and extracellular signal-regulated kinases 1/2 (ERK1/2).?Meanwhile, MCL markedly promoted antioxidant protein heme oxygenase-1 (HO-1) expression by enhancing NF-E2-related factor 2 (Nrf2) activity.?Together, ?MCL may serve as a neuroprotective agent in neuroinflammation-related neurodegenerative disorders. |
| CAS No. | 68370-47-8 |
| Chemical Formula | C15H20O3 |
| Molecular Weight | 248.322 |
| Solubility | DMSO: 49 mg/mL (197.32 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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