Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 5 mg | In stock | $ 71 | |
| 10 mg | In stock | $ 89 | |
| 50 mg | In stock | $ 109 | |
| 100 mg | In stock | $ 212 |
| Description | Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research. |
| In vitro | Fidaxomicin selectively eradicates pathogenic Clostridium difficile with minimal disruption to the multiple species of bacteria that make up the normal, healthy intestinal flora.Fidaxomicin is not inhibitory to commonly cultured bowel commensals (MIC90 >1024 μg/mL). |
| In vivo | Fidaxomicin (0-5 mg/kg, Orally, once a day for 5 days) completely prevents the lethality of the animals and prevents the occurrence of relapses in a hamster model for pseudomembranous colitis. |
| Synonyms | OPT-80; PAR-101 |
| CAS No. | 873857-62-6 |
| Chemical Formula | C52H74Cl2O18 |
| Molecular Weight | 1058.04 |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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