Purdue Bioscience - SpeciPure

Enmein shows a significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 μg/ml to 8.2 μg/ml.

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Description	Enmein shows a significant inhibitory effect toward human tumor cell K562 with IC(50) values ranging from 3.2 μg/ml to 8.2 μg/ml.
In vitro	Four new ent-kaurane diterpenoids, sculponeatins F-I (1-4), together with six known compounds, sculponeatin E (5), epi-nodosin (6), epi-nodosinol (7), Enmein (8), and macrocalyxoformins A and B (9 and 10), were isolated from the leaves of Isodon sculponeata. Also obtained were ursolic acid, 2alpha,3beta-dihydroxy-urs-12-en-28-oic acid, 2alpha,3beta,19alpha-trihydroxy-urs-12-en-28-oic acid, beta-sitosterol, daucosterol, quercetin, pedalitin, rosmarinic acid, caffeic acid and ethyl caffeic acid. Their structures were determined by spectral methods (1D-, 2D-NMR and MS). Some diterpenoids were tested for their cytotoxicity to inhibit three kinds of human tumor cells K562, A549 and T24.
CAS No.	3776-39-4
Chemical Formula	C20H26O6
Molecular Weight	362.422
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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