Apoptosis

Apoptosis is an autonomous, genetically controlled, orderly death of cells to maintain the stability of the internal environment. Unlike necrosis, apoptosis is not a passive process, but an active one, involving the activation, expression and regulation of a series of genes, and it is not a phenomenon of autologous damage under pathological conditions, but an active death process for better adaptation to the survival environment. Apoptosis is a fundamental biological phenomenon of cells and plays a necessary role in the removal of unwanted or abnormal cells in multicellular organisms. It plays an important role in the evolution of organisms, the stability of the internal environment, and the development of several systems. Apoptosis is not only a specific type of cell death, but also has important biological significance and complex molecular biological mechanisms.

Cat. No.	Product name
BP10436	GSK-J4
BP10436	GSK-J4 is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a cell-free assay and inactive against a panel of demethylases of the JMJ family.
BP10463	Guanfu base A
BP10463	Guanfu base A is a potent noncompetitive CYP2D6 inhibitor (Ki: 1.20 μM in HLMs; Ki: 0.37 μM for rCYP2D6). It also inhibits HERG channel current.
BP10509	Gusacitinib
BP10509	Gusacitinib (ASN-002) is spleen tyrosine kinase (SYK) and janus kinase (JAK) inhibitor (IC50: 5-46 nM).
BP10741	H3B-6527
BP10741	H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.
BP10669	HA15
BP10669	HA15 targets specifically BiP/GRP78/HSPA5. HA15 exhibits anti-cancerous activity on all melanoma cells tested, including cells isolated from patients and cells that developed resistance to BRAF inhibitors.
BP10579	Hck-IN-1
BP10579	Hck-IN-1 is a selective Nef-dependent Hck inhibitor (IC50s: 2.8 μM and >20 μM for Nef:Hck complex and Hck) with antiretroviral activity. Hck-IN-1 is a direct and wide HIV-1 Nef antagonist with an IC50 of 100-300 nM for wild-type HIV-1 replication.
BP10772	Hematoporphyrin dihydrochloride
BP10772	Hematoporphyrin dihydrochloride is a substrate for affinity chromatography of heme-binding proteins.
BP10666	Hemin
BP10666	Hemin is an iron-containing porphyrin and Heme oxygenase (HO)-1 inducer.
BP10425	Hexylresorcinol
BP10425	Hexylresorcinol is a substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.
BP10412	HG-14-10-04
BP10412	HG-14-10-04 is a potent and specific ALK inhibitor.
BP10727	HIF-2α-IN-2
BP10727	HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
BP10878	Hinokiflavone
BP10878	Hinokiflavone is a novel modulator of pre-mRNA splicing activity in vitro and in cellulo. Hinokiflavone blocks splicing of pre-mRNA substrates by inhibiting spliceosome assembly, specifically preventing B complex formation. Hinokiflavone is a SUMO protease inhibitor, inhibiting sentrin-specific protease 1 (SENP1) activity.Hinokiflavone has significant cytotoxicity, it has inhibition of MMP-9.
BP10490	HJC0152 hydrochloride
BP10490	HJC0152 is a signal transducer and activator of transcription 3 (STAT3) inhibitor.
BP10179	HLCL-61 hydrochloride
BP10179	HLCL-61 hydrochloride is a potent and selective PRMT5 inhibitor for the treatment of acute myeloid leukemia.
BP10188	HO-3867
BP10188	HO-3867, an analog of curcumin, is a sspecific STAT3 inhibitor.
BP10770	HOMOPLANTAGININ
BP10770	Homoplantaginin is a flavonoid from a traditional Chinese medicine Salvia plebeia,it has a protective and therapeutic effect on hepatocyte injury and shows potent inhibitory activities against influenza.
BP10522	HPOB
BP10522	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
BP10333	HS-173
BP10333	HS-173 is an effective PI3Kα inhibitor (IC50: 0.8 nM).
BP10703	hVEGF-IN-1
BP10703	hVEGF-IN-1 inhibits human VEGF-A translation and has antitumor activity.
BP10328	Hydroxyurea
BP10328	Hydroxyurea, an antineoplastic agent, inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.