Apoptosis

Apoptosis is an autonomous, genetically controlled, orderly death of cells to maintain the stability of the internal environment. Unlike necrosis, apoptosis is not a passive process, but an active one, involving the activation, expression and regulation of a series of genes, and it is not a phenomenon of autologous damage under pathological conditions, but an active death process for better adaptation to the survival environment. Apoptosis is a fundamental biological phenomenon of cells and plays a necessary role in the removal of unwanted or abnormal cells in multicellular organisms. It plays an important role in the evolution of organisms, the stability of the internal environment, and the development of several systems. Apoptosis is not only a specific type of cell death, but also has important biological significance and complex molecular biological mechanisms.

Cat. No.	Product name
BP10310	2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
BP10310	GDC046, a potent lead analog, has good kinase selectivity, physicochemical properties and pharmacokinetic profile.
BP10144	20(R)-Ginsenoside Rh2
BP10144	(R)Ginsenoside-Rh2 is a minor stereoisomer of ginsenoside Rh2, possesses matrix metalloproteinase inhibitory.
BP10487	20(S)-Ginsenoside Rg3
BP10487	Ginsenoside Rg3 possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells. It inhibits the proliferation of human umbilical vein endothelial cells(HUVEC) and has anti-angiogenesis activities.
BP10911	25R-Inokosterone
BP10911	25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
BP10907	25S-Inokosterone
BP10907	25S-Inokosterone and 25R-inokosterone exhibit potent inhibition (80-95% at ) against TNF-expression levels in A23187 plus phorbol-myrisrate acetate-induced RBL-2H3 cells, they have excellent anti-atopy activity, thus they could be used to a large range of functional anti-atopy cosmetics.
BP10632	2-Deoxy-D-glucose
BP10632	2-Deoxy-D-glucose is an analog of glucose, which is a glycolytic inhibitor with antiviral activity.
BP10363	2-HBA
BP10363	2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.
BP10757	2-Hydroxy-3-methylanthraquinone
BP10757	2-Hydroxy-3-methylanthraquinone enhances apoptosis of U937 cells,in part,through activation of p-p38MAPK and downregulation of p-ERK1/2; triggers caspase-3 activation mediated apoptotic induction.
BP10599	2-methoxycinnamaldehyde
BP10599	2-Methoxycinnamaldehyde (2-MCA) is a natural compound of Cinnamomum cassia,has been widely studied with regard to its antitumor activity.
BP10138	3-Bromopyruvic acid
BP10138	3-Bromopyruvic acid is a hexokinase II inhibitor with Ki of 2.4 mM for glycolysis/hexokinase inhibition. It is inhibitor of tumour cell energy metabolism and chemopotentiator of platinum drugs.
BP10586	3-O-Methylquercetin tetraacetate
BP10586	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
BP10894	4-Hydroxycinnamamide
BP10894	4-Hydroxycinnamamide has antioxidant activity. 4-Hydroxycinnamamide derivatives are specific inhibitors of tyrosine-specific protein kinases.
BP10993	4-Methyldaphnetin
BP10993	1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide anion radicals and of aqueous alkylperoxyl radicals, but may be pro-oxidant (enhancing generation of hydroxyl radicals) in the presence of free iron ions.2. 4-Methyldaphnetin inhibits the proinflammatory 5-lipoxygenase enzyme at micromolar concentrations.
BP10517	5-(N,N-Hexamethylene)-amiloride
BP10517	HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 μM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 μM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 μM.
BP10335	5,7-Dimethoxyflavanone
BP10335	5,7-Dimethoxyflavanone has anti-inflammatory activity.
BP10167	5-Hydroxy-7,8-dimethoxyflavanone
BP10167	5-Hydroxy-7,8-dimethoxyflavanone is isolated from Andrographis paniculata Nees. leaves and roots with anti-inflammatory activity.
BP10897	5-phenylthieno[2,3-d]pyrimidin-4-amine
BP10897	5-phenylthieno[2,3-d]pyrimidin-4-amine is a chemical compound.
BP10370	5α-Hydroxycostic acid
BP10370	5alpha-Hydroxycostic acid possesses anti-angiogenic ability by interfering the VEGF- and Ang2-related pathways, and it may be a good drug candidate.
BP10865	6,4'-Dihydroxy-7-methoxyflavanone
BP10865	6,4'-Dihydroxy-7-methoxyflavanone is a biologically active compound isolated from the heartwood of Dalbergia odorifera T. Chen (Leguminosae) with antioxidant, anti-inflammatory and neuroprotective effects. 6,4'-Dihydroxy-7-methoxyflavanone can be used in studies about the treatment of osteoclastogenic bone diseases such osteoporosis, rheumatoid arthritis and periodontal diseases.
BP10637	6-Thioguanine
BP10637	Thioguanine is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.