Apoptosis

Apoptosis is an autonomous, genetically controlled, orderly death of cells to maintain the stability of the internal environment. Unlike necrosis, apoptosis is not a passive process, but an active one, involving the activation, expression and regulation of a series of genes, and it is not a phenomenon of autologous damage under pathological conditions, but an active death process for better adaptation to the survival environment. Apoptosis is a fundamental biological phenomenon of cells and plays a necessary role in the removal of unwanted or abnormal cells in multicellular organisms. It plays an important role in the evolution of organisms, the stability of the internal environment, and the development of several systems. Apoptosis is not only a specific type of cell death, but also has important biological significance and complex molecular biological mechanisms.

Cat. No.	Product name
BP10107	Demethylzeylasteral
BP10107	Demethylzeylasteral has strong immunosuppressive activity, can be used in the fields of organ transplantation and autoimmune disorders. The risk of elevated serum concentrations of estradiol due to the inhibition of estradiol glucuronidation by Demethylzeylasteral. Demethylzeylasteral increases both activation and inactivation time constants of Ca(2+) currents, can inhibit significantly the sperm acrosome reaction initiated by progesterone.
BP10877	Deoxypodophyllotoxin
BP10877	Deoxypodophyllotoxin shows cytotoxic , antineoplastic, antitumor, insecticidal, anti-angiogenic, vascular disrupting, insecticidal, antiviral, and anti-inflammatory activities.
BP10740	Deracoxib
BP10740	Deracoxib is a non-steroidal, non-narcotic anti-inflammatory drug. It is also a selective cyclooxygenase-2 inhibitor, and IC50 Value: 70 to 150 μM(inhibition of 3 osteosarcoma cell lines).
BP10278	Derazantinib
BP10278	Derazantinib (ARQ-087) is an ATP competitive tyrosine kinase inhibitor. It exhibits potent activity against FGFR1/FGFR2/FGFR3 chondrocytes (IC50s: 4.5 nM/1.8 nM/4.5 nM).
BP10677	Desidustat
BP10677	Desidustat is an inhibitor of HIF hydroxylase.
BP10829	Desmethyl Erlotinib
BP10829	OSI-420 is the active metabolite of Erlotinib (EGFR inhibitor with IC50 of 2 nM).
BP10827	Desmethyl Erlotinib hydrochloride
BP10827	OSI-420 (Desmethyl Erlotinib, CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for human EGFR and EGFR autophosphorylation in tumor cells.
BP10822	Desmethylanethol trithione
BP10822	ADT-OH is a derivative of anethole dithiolethione (ADT) and synthetic hydrogen sulfide (H2S) donor. In the in vitro glucose-oxygen deprivation (OGD) model, ADT-OH markedly attenuated tPA-enhanced Akt activation and VEGF expression in brain microvascular endothelial cells. Finally, ADT-OH improved functional outcomes in mice subjected to MCAO and tPA infusion. H2S donors reduced tPA-induced cerebral hemorrhage by possibly inhibiting the Akt-VEGF-MMP9 cascade. Administration of H2S donors has potential as a novel modality to improve the safety of tPA following the stroke.
BP10668	Deucravacitinib
BP10668	BMS-986165 inhibits IL-12/23 and type I IFN pathways. BMS-986165 is a highly selective, orally bioavailable allosteric TYK2 inhibitor for the treatment of autoimmune diseases. Which selectively binds to TYK2 pseudokinase (JH2) domain (IC50=1.0 nM) and blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain.
BP10200	Diatrizoic Acid
BP10200	Diatrizoic Acid is an organic, iodinated radiopaque X-ray contrast medium used in diagnostic radiography.
BP10622	Diclofenac
BP10622	Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.
BP10621	Diclofenac Potassium
BP10621	Diclofenac potassium is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.
BP10620	Diclofenac sodium
BP10620	Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.
BP10512	Didymin
BP10512	Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.
BP10369	Dihydrocucurbitacin B
BP10369	Dihydrocucurbitacin B is isolated from the roots of Cayaponia tayuya with anti-cancer activity.
BP10605	DIM-C-pPhOH
BP10605	Nur77 (NR4A1) antagonist. Inhibits TGF-β induced cell migration of breast cancer cell lines. Promotes ROS/endoplasmic reticulum stress and proapoptotic pathways in pancreatic cancer cell lines. Mimics effects of Nur77 RNAi silencing.
BP10868	Dioscin
BP10868	Dioscin is a saponin with antitumor activities.
BP10480	Diosgenin glucoside
BP10480	Diosgenin glucoside and other synthetic glycosides with similar activities may be of use in the management of hypercholesterolemia and atherosclerosis. Significant inhibition of Diosgenin glucoside synthesis and stimulation of solasodine glucosylation was found only with PC molecular species containing fatty acids with a chain length of 12-18 carbon atoms.
BP10027	DL-alpha-Tocopherol
BP10027	Antioxidant.
BP10232	DMH-1
BP10232	DMH-1 is a potent and selective BMP inhibitor.