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BP16161
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SKF89976A hydrochloride
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SKF89976A hydrochloride is a selective inhibitor GABA transporter such as GAT-1 (IC50s = 0.28 μM), GAT-2 (IC50s = 137.34 μM) and GAT-3(IC50s = 202.8 μM) in CHO cells.
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BP16162
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Sodium ionophore III
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Sodium ionophore III (ETH2120) is a Na+ ionophore suitable for the test of sodium activity in plasma, serum, and blood.
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BP16163
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Sparteine sulfate
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Sparteine sulfate is a class 1a antiarrhythmic agent and a sodium channel blocker. It can chelate the bivalents calcium and magnesium.
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BP16164
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SR33805
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SR33805 is a potent antagonist of Ca2+ channel(EC50s of 4.1 nM and 33 nM in depolarized and polarized conditions, respectively)
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BP16165
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Synta66
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Synta66 is a store-operated calcium entry channel Orai inhibitor, and used for the research of neurological disease.
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BP16166
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Tanshinone IIA sulfonate sodium
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Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca2+ entry (SOCE), and is used to treat cardiovascular disorders.
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BP16167
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Tariquidar
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Tariquidar (XR9576) is a potent and specific inhibitor of P-glycoprotein (P-gp) with the high affinity (Kd=5.1 nM).
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BP16168
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Taxezopidine L
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Taxezopidines K and taxezopidine L can markedly inhibit Ca2+-induced depolymerization of microtubules.
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BP16169
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Taxinine
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Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
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BP16170
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Taxol C
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Taxol C can reduce interaction with the P-glycoprotein transporter that may allow for increased permeation of taxanes into the brain.
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BP16171
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Taxuspine X
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Taxuspine X may have p-glycoprotein inhibitory activity.
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BP16172
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TC-AQP1-1
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TC-AQP1-1 is a blocker of the aquaporin 1 channel identified by virtual screening and inhibits water flux through hAQP1 in Xenopus laevis oocyte swelling assays at low micromolar concentrations.
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BP16173
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TC-I2000
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TC-I2000 is an TRPM8 channel blocker. Inhibits icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells with IC50 of 53 nM.
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BP16174
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TCN 201
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TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC50 of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC50<4.3).
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BP16175
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Chembridge-5861528
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TCS5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx with IC50 values of 14.3 and 18.7 μM, respectively.
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BP16176
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Tegoprazan
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Tegoprazan is a potassium-competitive acid blocker and is a potent, oral active, and highly selective inhibitor of gastric H+/K+-ATPase. That could control gastric acid secretion and motility (IC50: ranging from 0.29-0.52 μM for porcine, canine, and human H+/K+-ATPases in vitro).
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BP16177
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Temgicoluril
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Temgicoluril acts on GABA Receptor.
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BP16178
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Tenapanor
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Tenapanor (AZD1722) is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor has the potential for the research of hyperphosphatemia.
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BP16179
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Tepotinib hydrochloride(1 : x)
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Tepotinib hydrochloride(1 : x) is an orally bioavailable, mesenchymal-epithelial transition (MET) TKI developed mainly for selected NSCLC patients with METex14 skipping mutations.
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BP16180
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11Beta-hydroxyprogesterone
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The progesterone derivatives 11 alpha- and 11 beta-hydroxyprogesterone are potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2) in vitro and can confer mineralocorticoid activity on corticosterone in the rat in vivo. 11beta-Hydroxyprogesterone acts as a mineralocorticoid agonist in stimulating Na+ absorption in mammalian principal cortical collecting duct cells.
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