Epigenetics

Epigenetics is the control of gene expression without altering the DNA sequence, including DNA methylation, genomic imprinting, maternal effects, gene silencing, nucleolus dominant, dormant transposon activation, and RNA editing. In contrast to classical genetics, which focuses on the effects of gene sequences on biological functions, epigenetics focuses on the mechanisms by which these "epigenetic phenomena" are established and maintained.

Cat. No.	Product name
BP13678	NKL 22
BP13678	An effective Histone Deacetylase Inhibitor.
BP13677	Ampkinone
BP13677	Ampkinone is an indirect AMPK activator.
BP13676	Amodiaquine
BP13676	Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
BP13675	Amodiaquine dihydrochloride dihydrate
BP13675	Amodiaquine Hydrochloride is the hydrochloride salt of amodiaquine, an orally active 4-aminoquinoline derivative with antimalarial and anti-inflammatory properties.
BP13674	Amifostine trihydrate
BP13674	Amifostine is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
BP13673	Amifostine
BP13673	Amifostine anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
BP13672	AMI-1
BP13672	AMI-1 is an effective and selective Histone Methyltransferase (HMT) inhibitor (IC50: 3.0/8.8 μM, for yeast Hmt1p, and human PRMT1).
BP13671	Alobresib
BP13671	Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.
BP13670	AK-7
BP13670	AK-7 is a brain-permeable SIRT2 inhibitor and to characterize its cholesterol-reducing properties in neuronal models with an IC50 of 15.5 μM.
BP13669	AK-1
BP13669	AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 μM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
BP13621	Agrimol B
BP13621	Agrimol B is a main active ingredient isolated from Agrimonia pilosa Ledeb.
BP13668	AG14361
BP13668	AG14361 is an effective inhibitor of PARP1 (Ki<5 nM).
BP13667	AES-135
BP13667	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
BP13666	Adenosine 5'-monophosphate monohydrate
BP13666	Adenosine monophosphate (AMP), also known as 5'-adenylic acid, is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid and the nucleoside adenosine. AMP consists of a phosphate group, the sugar ribose, and the nucleobase adenine. As a substituent it takes the form of the prefix adenylyl-.
BP13665	Adenosine monophosphate
BP13665	Adenosine 5'-monophosphate is an ester of phosphoric acid with the nucleoside adenosine.
BP13664	ACY-957
BP13664	ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/7/8/9.
BP13663	ACY-775
BP13663	ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
BP13662	ACY-738
BP13662	ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
BP13661	Citarinostat
BP13661	ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. Upon oral administration, ACY-241 inhibits the activity of HDACs; this results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This leads to the inhibition of tumor oncogene transcription, and the selective transcription of tumor suppressor genes, which inhibit tumor cell division and induce tumor cell apoptosis.
BP13660	ACY-1083
BP13660	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM). It is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY-1083 effectively reverses chemotherapy-induced peripheral neuropathy.