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BP13698
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AZD5305
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AZD5305 is a potent, selective and oral active PARP inhibitor.
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BP13697
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AZD5153 6-Hydroxy-2-naphthoic acid
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AZD5153 (6- Hydroxy- 2- naphthoic Acid) is a potent triazolopyridazine-based Bromodomain (BRD4) and Extraterminal (BET) inhibitor used in cancer treatments.
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BP13696
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AZD-2461
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AZD2461 is a novel PARP inhibitor.
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BP13695
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Barasertib
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AZD1152 is a pro-drug of Barasertib-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.
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BP13694
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AZ9482
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AZ9482 is a selective and potent inhibitor of PARP featuring an amide linkage to a 2-piperazinyl-3-cyano-pyridine. AZ9482 exhibits very potent activity of centrosome declustering with EC50 of < 18 nM in HeLa cells.
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BP13693
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AZ6102
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AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
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BP13692
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AZ505
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AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).
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BP13691
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AZ505 ditrifluoroacetate
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AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).
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BP13690
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Ayanin
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Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma. The IC50 value of Ayanin is 2.2microM for inhibiting interleukin IL-4 production from purified basophils. Ayanin is a non-selective phosphodiesterase1-4 inhibitor and can be used for respiratory disease researches.
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BP13689
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Cycloastragenol
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Astramembrangenin (Cycloastragenol) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression
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BP13688
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ASP4132
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ASP4132 is an orally active AMPK activator (EC50 : 18 nM), has anti-cancer activity.
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BP13687
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AS8351
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AS-8351 is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblasts into functional cardiomyocytes.
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BP13686
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AS2521780
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AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
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BP13685
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ARV-825
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ARV-825, a heterobifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon leading to fast, efficient, and prolonged degradation of BRD4 in all BL cell lines tested.
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BP13684
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ARV-771
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ARV-771 is a potent BET degrader based on PROTAC technology with Kds of 34, 4.7, 8.3, 7.6, 9.6, and 7.6 nM for BRD2(1), BRD2(2), BRD3(1), BRD3(2), BRD4(1), and BRD4(2), respectively.
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BP13683
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ARN-3236
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ARN-3236 is an oral active and selective inhibitor of salt-inducible kinase 2 (SIK2), (SIK2, SIK1 and SIK3 with IC50s of <1 nM, 21.63 nM and 6.63 nM respectively). ARN-3236 Has anti-cancer activity.
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BP13682
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AR42
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AR-42 is an HDAC inhibitor (IC50: 30 nM).
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BP13681
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Apicidin
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Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative activity.
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BP13680
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Acetaminophen
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Analgesic antipyretic derivative of acetanilide. Acetaminophen has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
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BP13679
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Anacardic Acid
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Anacardic Acid is an effective inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases. It also has antimicrobial activity, antibacterial activity, and inhibits prostaglandin synthase, lipoxygenase, and tyrosinase.
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