Transient receptor potential (TRP) proteins are a diverse family of proteins with structural features typical of ion channels subfamily which are Ca (2+)-permeable cation channels localized predominantly to the plasma membrane. TRPM5 plays a central role in taste transduction. TRPM5 is implicated in enhancing TRPA1 expression and may be involved in regulating insulin secretion. Alternative splicing results in transcript variants encoding distinct isoforms with calculated molecular weights of 98 kDa or 131 kDa. It has been reported that TRPM5 is N-linked glycosylated at a unique site and TRPM5 glycosylation seems not to be involved in channel trafficking, but mainly in its functional regulation.
| Description | Transient receptor potential (TRP) proteins are a diverse family of proteins with structural features typical of ion channels subfamily which are Ca (2+)-permeable cation channels localized predominantly to the plasma membrane. TRPM5 plays a central role in taste transduction. TRPM5 is implicated in enhancing TRPA1 expression and may be involved in regulating insulin secretion. Alternative splicing results in transcript variants encoding distinct isoforms with calculated molecular weights of 98 kDa or 131 kDa. It has been reported that TRPM5 is N-linked glycosylated at a unique site and TRPM5 glycosylation seems not to be involved in channel trafficking, but mainly in its functional regulation. |
| Tested Applications | WB: 1:1000; IF: 1:100-1:300; IHC:1:50-1:200 |
| Species Reactivity | Human, Mouse, Rat |
| Host Species/Isotype | Rabbit/IgG |
| Molecular Weight | 98 kDa |
| GenBank | BC093787 |
| Uniprot | Q9NZQ8 |
| Concentration | 540 μg/ml |
| Form | Liquid |
| Storage Instruction | 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do Not Aliquot. |
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