Pagoclone is a GABA receptor agonist and can be used for studies on the treatment of stuttering, panic disorder, and generalized anxiety. Pagoclone is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containi
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 2 mg | In stock | $ 155 | |
| 4 mg | In stock | $ 294 | |
| 8 mg | In stock | $ 394 | |
| 20 mg | In stock | $ 831 | |
| 40 mg | In stock | $ 1263 |
| Description | Pagoclone is a GABA receptor agonist and can be used for studies on the treatment of stuttering, panic disorder, and generalized anxiety. Pagoclone is a partial agonist at α1-, α2- and α5-containing GABAA receptors and a full agonist at receptors containi |
| In vitro | Pagoclone (3 mg/kg, p.o.) produces a dose-dependent increase in time spent on the open arms. Pagoclone (1, 3 or 10 mg/kg) lowers the cumulative chain-pulling response in the response sensitivity test. Plasma pagoclone concentrations are dose-dependent but not linear, with plasma concentrations of pagoclone being 0.4±0.1, 1.1±0.2 and 2.2±0.2 ng/mL, respectively. Pagoclone (3 mg/kg, p.o.) has significant anxiolytic-like activity, but Pagoclone(0.3, 1, 3 mg/kg p.o.) produces a significant reduction in the total distance travelled. |
| Synonyms | CI-1043, RP-62955, IP456, IP-456, CI1043, RP-59037 |
| CAS No. | 133737-32-3 |
| Chemical Formula | C23H22ClN3O2 |
| Molecular Weight | 407.9 |
| Solubility | DMSO: 8 mg/mL (19.61 mM), Need ultrasonic |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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