Purdue Bioscience - SpeciPure

Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 245
2 mg	In stock	$ 441
4 mg	In stock	$ 697
10 mg	In stock	$ 1303
20 mg	In stock	$ 2019

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Description	Zoniporide hydrochloride is a selective inhibitor of NHE-1 with IC50 of 14 nM which is >150-fold selectivity versus other NHE isoforms. Zoniporide hydrochloride shows an IC50 of 59 nM for NHE-1-dependent swelling of human platelets.
In vivo	In rats, Zoniporide hydrochloride (1 mg/kg; i.v.) shows the AUC0-∞ and t1/2 are 0.07 μg h/mL and 0.5 hours, respectively. In open chest anesthetized rabbits, Zoniporide hydrochloride (0.25, 1, 4 mg/kg; i.v.) dose-dependently reduces infarct size with an ED50 of 0.45 mg/kg/h. Zoniporide hydrochloride exhibits moderate plasma protein binding with t1/2 of 1.5h in monkeys.
CAS No.	241800-97-5
Chemical Formula	C17H17ClN6O
Molecular Weight	356.81
Solubility	DMSO: Soluble
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Zoniporide (hydrochloride)

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