(1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor.
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|---|---|---|---|
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| 10 mg | Inquiry | $ 171 | |
| 20 mg | Inquiry | $ 229 | |
| 50 mg | Inquiry | $ 494 | |
| 100 mg | Inquiry | $ 741 |
| Description | (1S)-(-)-Alpha-Pinene enhances the quantity of NREMS without affecting the intensity of NREMS by prolonging GABAergic synaptic transmission, acting as a partial modulator of GABAA-BZD receptors and directly binding to the BZD binding site of GABAA receptor. |
| In vitro | (1S)-(-)-Alpha-Pinene significantly increased the duration of non-rapid eye movement sleep (NREMS) and reduced the sleep latency by oral administration without affecting duration of rapid eye movement sleep and delta activity. (1S)-(-)-Alpha-Pinene potentiated the GABAA receptor-mediated synaptic response by increasing the decay time constant of sIPSCs in hippocampal CA1 pyramidal neurons. These effects of (1S)-(-)-Alpha-Pinene on sleep and inhibitory synaptic response were mimicked by zolpidem, acting as a modulator for GABAA-BZD receptors, and fully antagonized by flumazenil, an antagonist for GABAA-BZD receptor. (1S)-(-)-Alpha-Pinene was found to bind to aromatic residues of α1- and -γ2 subunits of GABAA-BZD receptors in the molecular model. |
| Synonyms | (1S)-(-)-Alpha-Pinene |
| CAS No. | 7785-26-4 |
| Chemical Formula | C10H16 |
| Molecular Weight | 136.238 |
| Solubility | DMSO: 50 mg/mL (367.03 mM), Need ultrasonic |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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